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    Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia. 
    Egnell, Christina; Heyman, Mats; Jónsson, Ólafur Gísli; Raja, Raheel A; Niinimäki, Riitta; Albertsen, Birgitte Klug; Schmiegelow, Kjeld; Stabell, Niklas; Vaitkeviciene, Goda; Lepik, Kristi; Harila-Saari, Arja; Ranta, Susanna (2022-03)
    Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2·0-17·9 years ...
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    Obesity does not modify the effect of continuous positive airway pressure on insulin resistance in adults with obstructive sleep apnoea 
    Pak, Victoria M; Maislin, David G; Keenan, Brendan T.; Guo, Xiaofeng; Townsend, Ray; Benediktsdóttir, Bryndís; Pack, Allan I.; Gíslason, Þórarinn; Kuna, Samuel T. (2023-03)
    This study found no evidence that obesity significantly modifies the effect of 4 months of CPAP treatment on HOMA-IR. Longer duration of CPAP treatment may be needed in order to reduce insulin resistance and determine whether obesity modifies the effect. ...
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    Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis : a NORD-STAR study 
    Dubovyk, Violetta; Vasileiadis, Georgios K.; Fatima, Tahzeeb; Zhang, Yuan; Kapetanovic, Meliha Crnkic; Kastbom, Alf; Rizk, Milad; Söderbergh, Annika; Zhao, Sizheng Steven; van Vollenhoven, Ronald F.; Hetland, Merete Lund; Haavardsholm, Espen A.; Nordström, Dan; Nurmohamed, Michael T.; Guðbjörnsson, Björn; Lampa, Jon; Østergaard, Mikkel; Heiberg, Marte Schrumpf; Sokka-Isler, Tuulikki; Gröndal, Gerður María; Lend, Kristina; Hørslev-Petersen, Kim; Uhlig, Till; Rudin, Anna; Maglio, Cristina (2024-04-04)
    OBJECTIVE: This report from the NORD-STAR (Nordic Rheumatic Diseases Strategy Trials and Registries) trial aimed to determine if obesity is associated with response to conventional and biological antirheumatic treatment in early rheumatoid arthritis ...
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    Obstructive Sleep Apnea Symptom Subtypes and Cardiovascular Risk : Conflicting Evidence to an Important Question 
    Keenan, Brendan T; Magalang, Ulysses J; Mazzotti, Diego R; McArdle, Nigel; Gíslason, Þórarinn; Singh, Bhajan; Maislin, Greg; Pack, Allan I (2021-12-13)
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    Occupational variation in incidence of oropharyngeal cancer in the Nordic countries 
    Nikkilä, Rayan; Mäkitie, Antti; Carpén, Timo; Hansen, Johnni; Heikkinen, Sanna; Lynge, Elsebeth; Selander, Jenny; Mehlum, Ingrid Sivesind; Torfadottir, Jóhanna Eyrún; Salo, Tuula; Pukkala, Eero (2024-01)
    Purpose: Evaluate the occupational variation in incidence of oropharyngeal cancer (OPC). Methods: We calculated standardized incidence ratios (SIRs) of OPC in occupational categories in the Nordic countries relative to the entire national populations. ...
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    Oestrogenic Regulation of Mitochondrial Dynamics 
    Kalkhoran, Siavash Beikoghli; Kararigas, Georgios (2022-02-01)
    Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific ...
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    Ofbeldi gagnvart starfsfólki geðdeilda Landspítala 
    Snorrason, Jón; Sigurðsson, Jón Friðrik (2022)
    Tilgangur: Ákveðið hlutfall starfsfólks á geðdeildum verður fyrir ofbeldi við störf sín. Fyrir flesta sem verða fyrir ofbeldi hefur það einhver áhrif. Þessi rannsókn sýnir umfang þessa vandamáls í geðþjónustu Landspítala. Aðferð: Rafrænn spurningalisti ...
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    Offita er ekki alltaf offita : Cushing-sjúkdómur, sjúkratilfelli 
    Björnsson, Aron Hjalti; Harðarson, Þorgeir Orri; Ólafsson, Ingvar Hákon; Ragnarsson, Óskar; Sigurjónsdóttir, Helga Ágústa (2020-10)
    Kona á fertugsaldri leitaði á bráðamóttöku með tveggja vikna sögu um versnandi höfuðverk og tvísýni. Hún hafði í um 8 ár leitað til lækna vegna þyngdaraukningar, sykursýki og háþrýstings og fengið ráðleggingar um heilbrigðan lífsstíl sem bar ekki ...
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    Ofþyngd þjóðar - hvað getum við gert? 
    Benediktsson, Rafn (2021-03)
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    Old question revisited : Are high-protein diets safe in pregnancy? 
    Halldórsson, Þórhallur Ingi; Birgisdóttir, Bryndís Eva; Brantsæter, Anne Lise; Meltzer, Helle Margrete; Haugen, Margaretha; Þórsdóttir, Inga; Ólafsdóttir, Anna Sigríður; Olsen, Sjurdur F. (2021-01-29)
    BACKGROUND: A previous randomized dietary intervention in pregnant women from the 1970s, the Harlem Trial, reported retarded fetal growth and excesses of very early preterm births and neonatal deaths among those receiving high-protein supplementation. ...
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    Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age 
    Spitzer, Sonia Olivia; Sitnikov, Sergey; Kamen, Yasmine; Evans, Kimberley Anne; Kronenberg-Versteeg, Deborah; Dietmann, Sabine; de Faria, Omar; Agathou, Sylvia; Káradóttir, Ragnhildur Thóra (2019-02-06)
    Spitzer et al. show that oligodendrocyte progenitor cells (OPCs) acquire ion channels and sensitivity to neuronal activity that differ between region and age. The onset and decline of ion channels follow developmental milestones. This heterogeneity ...
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    On Danish Borders: Icelandic Sagas in German Occupied Denmark 
    Helgason, Jón Karl (1994)
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    On predicting time to completion for the first stage of spontaneous labor at term in multiparous women 
    Gunnarsson, Björn; Skogvoll, Eirik; Røislien, Jo; Smárason, Alexander Kristinn; Jónsdóttir, Ingibjörg Hanna (2017-06-12)
    Background Labor that progresses faster than anticipated may lead to unplanned out-of-hospital births. With the aim to improve planning of transportation to birthing institutions, this study investigated predictors of time to completion for the first ...
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    Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humans 
    van Keulen, Danielle; Pouwer, Marianne G.; Emilsson, Valur; Matic, Ljubica Perisic; Pieterman, Elsbet J.; Hedin, Ulf; Gudnason, Vilmundur; Jennings, Lori L.; Holmstrøm, Kim; Nielsen, Boye Schnack; Pasterkamp, Gerard; Lindeman, Jan H.N.; van Gool, Alain J.; Sollewijn Gelpke, Maarten D.; Princen, Hans M.G.; Tempel, Dennie (2019-08-01)
    Objective Previous studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in development. However, to date no intervention studies with OSM have been performed, and ...
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    Opinion on the impact of non-monotonic dose responses on EFSA′s human health risk assessments 
    EFSA Scientific Committee (2021-10-01)
    This Opinion assesses the biological relevance of the non-monotonic dose responses (NMDR) identified in a previous EFSA External Report (Beausoleil et al., 2016) produced under GP/EFSA/SCER/2014/01 and the follow-up probabilistic assessment (Chevillotte ...
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    Opioids for Treatment of Pre-hospital Acute Pain : A Systematic Review 
    Friesgaard, Kristian Dahl; Vist, Gunn Elisabeth; Hyldmo, Per Kristian; Raatiniemi, Lasse; Kurola, Jouni; Larsen, Robert; Kongstad, Poul; Magnússon, Viðar; Sandberg, Mårten; Rehn, Marius; Rognås, Leif (2022-01-18)
    Introduction: Acute pain is a frequent symptom among patients in the pre-hospital setting, and opioids are the most widely used class of drugs for the relief of pain in these patients. However, the evidence base for opioid use in this setting appears ...
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    Optic Nerve Subarachnoid Space Posture Dependency - An MRI Study in Subjects With Normal Tension Glaucoma and Healthy Controls 
    Kristiansen, Martin; Holmlund, Petter; Lindén, Christina; Eklund, Anders; Jóhannesson, Gauti (2023-12-01)
    PURPOSE: The purpose of this study was to examine the differences of optic nerve subarachnoid space (ONSAS) volume in patients with normal tension glaucoma (NTG) and healthy controls in different body positions. METHODS: Eight patients with NTG and ...
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    Optimal communication associated with lower risk of acute traumatic stress after lung cancer diagnosis 
    Harðardóttir, Hrönn; Aspelund, Thor; Zhu, Jianwei; Fall, Katja; Hauksdóttir, Arna; Fang, Fang; Lu, Donghao; Janson, Christer; Jónsson, Steinn; Valdimarsdóttir, Heiðdís; Valdimarsdóttir, Unnur Anna; Hardardottir, Hronn (2022-01)
    Purpose: The aim of this study was to assess the role of the patient’s background and perceived healthcare-related factors in symptoms of acute stress after lung cancer diagnosis. Methods: The study population consisted of 89 individuals referred for ...
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    Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasma 
    Thorsteinsdottir, Unnur A; Runólfsdóttir, Hrafnhildur L.; Eiríksson, Finnur Freyr; Ágústsd., Inger María Schweitz; Eðvarðsson, Viðar Örn; Pálsson, Runólfur; Þorsteinsdóttir, Margrét (2024-03-01)
    Adenine phosphoribosyltransferase (APRT) deficiency is a rare , hereditary disorder characterized by renal excretion of 2,8-dihydroxyadenine (DHA), leading to kidney stone formation and chronic kidney disease (CKD). Treatment with a xanthine oxidoreductase ...
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    Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy : EuGMS SIG on pharmacology position paper 
    EuGMS SIG Pharmacology (2023-12)
    Inappropriate polypharmacy is highly prevalent among older adults and presents a significant healthcare concern. Conducting medication reviews and implementing deprescribing strategies in multimorbid older adults with polypharmacy are an inherently ...