Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Spitzer, Sonia Olivia; Sitnikov, Sergey; Kamen, Yasmine; Evans, Kimberley Anne; Kronenberg-Versteeg, Deborah; Dietmann, Sabine; de Faria, Omar; Agathou, Sylvia; Káradóttir, Ragnhildur Thóra

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Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Titill:	Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
Höfundur:	Spitzer, Sonia Olivia Sitnikov, Sergey Kamen, Yasmine Evans, Kimberley Anne Kronenberg-Versteeg, Deborah Dietmann, Sabine de Faria, Omar Agathou, Sylvia Káradóttir, Ragnhildur Thóra 9 höfundar Sýna færri höfunda
Útgáfa:	2019-02-06
Tungumál:	Enska
Umfang:	4839955
Deild:	Faculty of Medicine
Birtist í:	Neuron; 101(3)
ISSN:	0896-6273
DOI:	10.1016/j.neuron.2018.12.020
Efnisorð:	bioelectricity; differentiation; electrophysiology; glia; glutamate; ion channels; myelin; neurotransmitter receptors; oligodendrocyte; oligodendrocyte precursor cell; General Neuroscience
URI:	https://hdl.handle.net/20.500.11815/4043
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Tilvitnun: Spitzer , S O , Sitnikov , S , Kamen , Y , Evans , K A , Kronenberg-Versteeg , D , Dietmann , S , de Faria , O , Agathou , S & Káradóttir , R T 2019 , ' Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age ' , Neuron , vol. 101 , no. 3 , pp. 459-471.e5 . https://doi.org/10.1016/j.neuron.2018.12.020
Útdráttur: Spitzer et al. show that oligodendrocyte progenitor cells (OPCs) acquire ion channels and sensitivity to neuronal activity that differ between region and age. The onset and decline of ion channels follow developmental milestones. This heterogeneity indicates different functional states of OPCs.
Athugasemdir: We thank J. Trotter (Johannes Gutenberg University, Mainz, Germany) for the NG2-EYFP mice, Dr. Moritz Matthey for help with minipump transplantation, Miss Mariann Kovacs with embryonic dissection, and Dr. Katrin Volbracht for critical comments on the work. We acknowledge the support of the Wellcome – MRC Cambridge Stem Cell Institute core facility managers, in particular for this work Dr. Maike Paramor and Miss Victoria Murray with RNA-seq, and all staff members of the University Biomedical Services (UBS). This project has received the following funding: funding from the European Research Council (ERC) under the European Union Horizon 2020 Research and Innovation Program (grant agreement 771411 to R.T.K. and K.A.E.), a Wellcome Trust research career development fellowship (091543/Z/10/Z to R.T.K. and K.A.E.) and studentship (102160/Z/13/Z to Y.K.), Paul G. Allen Frontiers Group Allen Distinguished Investigator Award 12076 (to R.T.K., D.K.-V., and K.A.E.), a Medical Research Council studentship (to S.O.S.), a Gates Cambridge Trust Gates scholarship (to S.S.), a Biotechnology and Biological Sciences Research Council studentship (to S.A.), a Homerton College Cambridge junior research fellowship (to D.K.-V.), UK MS Society Cambridge Myelin Repair Centre grant 50 (to R.T.K. and O.d.F.), a Fonds de Recherche du Québec - Santé scholarship (to Y.K.), a Cambridge Commonwealth, European and International Trust scholarship (to Y.K.), and a Lister Institute research prize (to R.T.K., K.A.E., and S.O.S.). Publisher Copyright: © 2018 The Author(s)