- Opin vísindi
- →
- Fletta eftir efnisorði
JavaScript is disabled for your browser. Some features of this site may not work without it.
Fletta eftir efnisorði "Erfðafræði"
Atriði 21-40 af 101
-
(MDPI AG, 2018-12-13)Fluoropyrimidine-based chemotherapy is extensively used for the treatment of solid cancers, including colorectal cancer. However, fluoropyrimidine-driven toxicities are a major problem in the management of the disease. The grade and type of the ... -
(2021-06-02)Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed ...
-
(MDPI AG, 2019-11-07)Microbial communities in remote locations remain under-studied. This is particularly true on glaciers and icecaps, which cover approximately 11% of the Earth’s surface. The principal reason for this is the inaccessibility of most of these areas due ...
-
(Springer Science and Business Media LLC, 2019-08-13)Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated ...
-
(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-05)The DNA damage response is crucial to maintaining the integrity of DNA and the health of a cell. Unrepaired lesions within the DNA can lead to genomic instability and potentially aid in the formation of diseases such as cancer. Some cancers possess ...
-
(2021-11-24)(Cell 184, 4784–4818.e1–e16, September 2, 2021) In this article, we carried out a multi-cohort GWAS meta-analysis for 11 osteoarthritis phenotypes. Since publication, we have become aware of the following typographical errors that were introduced during ...
-
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 (Springer Science and Business Media LLC, 2018-07-17)Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants ...
-
(Springer Science and Business Media LLC, 2019-11-01)Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has ...
-
(Springer Nature, 2017-08-08)A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported ...
-
(Public Library of Science (PLoS), 2005-03-15)Lack of knowledge about how regulatory regions evolve in relation to their structure–function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a ...
-
(University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-12)Neurodevelopmental disorders on the impulsivity-compulsivity spectrum are chronic disabling conditions with an early onset. High rates of comorbidity have been reported between Tourette syndrome (TS), Tics disorder (Tics), obsessive compulsive ...
-
(Springer Nature, 2017-09-12)It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. ...
-
(2021-11)The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based ...
-
(University of Iceland, School of Health Sciences, Faculty of Medicine, 2021-10-08)Kransæðasjúkdómur dregur fleiri til dauða á hverju ári en nokkur annar sjúkdómur á heimsvísu. Sjúkdómurinn einkennist af framvindu æðakölkunar, sem er flókið og margþætt ferli. Á undanförnum 14 árum hafa rannsóknir með víðtækri erfðamengisleit leitt ...
-
(University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-06)Introduction and aims: Development of the nervous system is a complex and highly regulated process that, when impaired, can result in a multitude of disorders of varying behavioural, cognitive, and functional severity. Variation in brain structure and ...
-
(Springer Nature, 2018-03-07)Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up ...
-
(Springer Science and Business Media LLC, 2019-04-15)Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and ...
-
(Springer Science and Business Media LLC, 2018-11-30)Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genomewide association studies of gallstone disease in Iceland and the UK, totaling ...
-
(Springer Science and Business Media LLC, 2018-09-26)The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic ...
-
(2021-01-30)Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease ...
Atriði 21-40 af 101