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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits


Titill: Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Höfundur: Justice, Anne E.
Winkler, Thomas W.
Feitosa, Mary F.
Graff, Misa
Fisher, Virginia A.
Young, Kristin
Barata, Llilda
Deng, Xuan
Czajkowski, Jacek
Hadley, David
... 307 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-04-26
Tungumál: Enska
Umfang: 14977
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Nature Communications;8
ISSN: 2041-1723
DOI: 10.1038/ncomms14977
Efnisorð: Epidemiology; Genetics research; Genome-wide association studies; Obesity; Offita; Reykingar; Erfðafræði; Rannsóknir
URI: https://hdl.handle.net/20.500.11815/378

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Tilvitnun:

Justice, A. E., Winkler, T. W., Feitosa, M. F., Graff, M., Fisher, V. A., Young, K., . . . Cupples, L. A. (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 8, 14977. doi:10.1038/ncomms14977

Útdráttur:

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

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