Opin vísindi

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium


Titill: Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium
Höfundur: Weng, Lu-Chen
Lunetta, Kathryn L.
Müller-Nurasyid, Martina
Smith, Albert Vernon
Thériault, Sébastien
Weeke, Peter E.
Barnard, John
Bis, Joshua C.
Lyytikäinen, Leo-Pekka
Kleber, Marcus E.
... 60 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-09-12
Tungumál: Enska
Umfang: 11303
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Scientific Reports;7(1)
ISSN: 2045-2322
DOI: 10.1038/s41598-017-09396-7
Efnisorð: Cardiology; Genome-wide association studies; Hjartasjúkdómar; Háþrýstingur; Aldurshópar; Líkamsþyngd; Erfðafræði; Rannsóknir
URI: https://hdl.handle.net/20.500.11815/443

Skoða fulla færslu

Tilvitnun:

Weng, L.-C., Lunetta, K. L., Müller-Nurasyid, M., Smith, A. V., Thériault, S., Weeke, P. E., . . . Lubitz, S. A. (2017). Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium. Scientific Reports, 7(1), 11303. doi:10.1038/s41598-017-09396-7

Útdráttur:

It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10−5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10−8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk.

Leyfi:

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Skrár

Þetta verk birtist í eftirfarandi safni/söfnum:


Fletta

Um vefinn

Reikningurinn minn