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A genome-wide association study yields five novel thyroid cancer risk loci

A genome-wide association study yields five novel thyroid cancer risk loci


Titill: A genome-wide association study yields five novel thyroid cancer risk loci
Höfundur: Guðmundsson, Júlíus
Þorleifsson, Guðmar
Sigurðsson, Jón K.
Stefánsdóttir, Lilja
Jónasson, Jón G.
Guðjónsson, Sigurjón Axel
Gudbjartsson, Daniel   orcid.org/0000-0002-5222-9857
Másson, Gísli   orcid.org/0000-0003-0493-8242
Jóhannsdóttir, Hrefna
Halldórsson, Gísli H.
... 30 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-02-14
Tungumál: Enska
Umfang: 14517
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Verkfræði- og náttúruvísindasvið (HÍ)
School of Engineering and Natural Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Nature Communications;8
ISSN: 2041-1723
DOI: 10.1038/ncomms14517
Efnisorð: Cancer genetics; Genome-wide association studies; Krabbamein; Erfðafræði; Rannsóknir
URI: https://hdl.handle.net/20.500.11815/304

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Tilvitnun:

Gudmundsson, J. et al. A genome-wide association study yields five novel thyroid cancer risk loci. Nat. Commun. 8, 14517 doi: 10.1038/ncomms14517 (2017).

Útdráttur:

The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10−8): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10−7) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.

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