Introduction and aims: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and its complex pathophysiology is incompletely understood. At the time of beginning of this work, genome-wide association studies (GWAS) on AF had yielded ...

Purpose and aims: Multiple sclerosis (MS) is an autoimmune disease that leads to damage in the central nervous system. Although the cause of MS is still unknown, the generally accepted view is that environmental and life-style factors influence the ...

Þekkt er að kæling frumna (32-36°C) eykur tjáningu fáeinna þekktra gena. Margt er á huldu um þá innanfrumu- og millifrumuferla sem kæling snertir við og kallaðir hafa verið kælisvarið. Kæling er notuð í læknisfræðilegum tilgangi til að fá fram ...

Íslenski hesturinn er eini hestastofninn á Íslandi. Hestar voru fluttir hingað við landnám og hafa verið hreinræktaðir síðan. Vegna landfræðilegrar einangrunar er stofninn berskjaldaður fyrir mörgum sjúkdómsvöldum sem herja á hesta í öðrum löndum. ...

Aim: The aim of this Ph.D. thesis is to enhance understanding of the relation between maternal diet, gestational weight gain (GWG), and offspring’s cardio-metabolic factors. Moreover, the objective is to identify dietary predictors for excessive GWG. ...

The ocean represents a tremendous source of biologically active metabolites with great potential for the development of new pharmaceuticals. Marine sponges and their microbial associates are known as the most prolific source of structurally diverse and ...

Markmið: Að kanna áhættuþætti fyrir fæðingu mikilla þungbura (fæðingarþyngd ≥5000 g) og hugsanlegar afleiðingar þess fyrir móður og barn (grein 1). Að meta efnaskipti mikilla þungbura með því að skoða mynstur þeirra amínósýra og acylkarnitína sem mæld ...

A better understanding of normal organ development can give deeper insight into which genes are harnessed by aberrant cells during cancer formation and progression. In my thesis, I have investigated two seemingly different, however, related, developmental ...

Neurodevelopmental disorders on the impulsivity-compulsivity spectrum are chronic disabling conditions with an early onset. High rates of comorbidity have been reported between Tourette syndrome (TS), Tics disorder (Tics), obsessive compulsive ...

Introduction and aims: Development of the nervous system is a complex and highly regulated process that, when impaired, can result in a multitude of disorders of varying behavioural, cognitive, and functional severity. Variation in brain structure and ...