dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Kamble, Nilesh Ramesh |
dc.contributor.author |
Gränz, Markus |
dc.contributor.author |
Prisner, Thomas F. |
dc.contributor.author |
Sigurdsson, Snorri |
dc.date.accessioned |
2020-08-10T15:21:54Z |
dc.date.available |
2020-08-10T15:21:54Z |
dc.date.issued |
2016 |
dc.identifier.issn |
1359-7345 |
dc.identifier.issn |
1364-548X (eISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1960 |
dc.description |
Post-print (lokagerð höfundar) |
dc.description.abstract |
An isoindoline-nitroxide derivative of guanine (G, "G-spin") was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance measurements on a G-labeled duplex RNA with PELDOR (DEER) showed a strong orientation dependence. Thus, G is a readily synthesized, orientation-selective spin label for "mix and measure" PELDOR experiments. |
dc.description.sponsorship |
This work was supported by the Deutsche Forschungsgemeinschaft DFG (SFB 902 Molecular Principles of RNA-based Regulation), the Icelandic Research Fund (141062051) and by a doctoral fellowship to N. R. K. from the University of Iceland Research Fund. We thank Dr S. Jonsdottir for assistance in collecting analytical data for structural characterization of the compounds. |
dc.format.extent |
14442-14445 |
dc.language.iso |
en |
dc.publisher |
Royal Society of Chemistry (RSC) |
dc.relation.ispartofseries |
Chemical Communications;52(100) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Nicotinamide adenine dinucleotide |
dc.subject |
Electron paramagnetic resonance |
dc.subject |
Nucleic acid structure |
dc.subject |
EPR spectroscopy |
dc.subject |
Isoindoline nitroxides |
dc.subject |
Alcohol dehydrogenase |
dc.subject |
Distance measurements |
dc.subject |
Abasic sites |
dc.subject |
DNA |
dc.subject |
Dynamics |
dc.subject |
Litrófsgreining |
dc.subject |
Kjarnsýrur |
dc.subject |
Rafeindir |
dc.title |
Noncovalent and site-directed spin labeling of duplex RNA |
dc.type |
info:eu-repo/semantics/article |
dc.description.version |
Peer reviewed |
dc.identifier.journal |
Chemical Communications |
dc.identifier.doi |
10.1039/C6CC08387K |
dc.relation.url |
http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC08387K |
dc.contributor.department |
Raunvísindadeild (HÍ) |
dc.contributor.department |
Faculty of Physical Sciences (UI) |
dc.contributor.department |
Raunvísindastofnun (HÍ) |
dc.contributor.department |
Science Institute (UI) |
dc.contributor.school |
Verkfræði- og náttúruvísindasvið (HÍ) |
dc.contributor.school |
School of Engineering and Natural Sciences (UI) |