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Browsing by Subject "DNA"

Browsing by Subject "DNA"

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    Dynamics of Nucleic Acids at Room Temperature Revealed by Pulsed EPR Spectroscopy 
    Gränz, Markus; Erlenbach, Nicole; Spindler, Philipp; Gophane, Dnyaneshwar B.; Stelzl, Lukas S.; Sigurdsson, Snorri; Prisner, Thomas F. (Wiley, 2018-08-13)
    The investigation of the structure and conformational dynamics of biomolecules under physiological conditions is challenging for structural biology. Although pulsed electron paramagnetic resonance (like PELDOR) techniques provide long‐range distance ...
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    Noncovalent and site-directed spin labeling of duplex RNA 
    Kamble, Nilesh Ramesh; Gränz, Markus; Prisner, Thomas F.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2016)
    An isoindoline-nitroxide derivative of guanine (G, "G-spin") was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance measurements on a G-labeled duplex RNA with PELDOR (DEER) showed a strong orientation dependence. Thus, ...
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    Noncovalent spin-labeling of RNA: the aptamer approach 
    Saha, Subham; Hetzke, Thilo; Prisner, Thomas F.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2018)
    In the first example of site-directed spin-labeling of unmodified RNA, a pyrrolidine-nitroxide derivative of tetramethylrosamine (TMR) was shown to bind with high affinity to the malachite green (MG) aptamer, as determined by continuous-wave (CW) ...
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    Noncovalent Spin‐Labeling of DNA and RNA Triplexes 
    Kamble, Nilesh Ramesh; Wolfrum, Manpreet; Halbritter, Thomas; Sigurdsson, Snorri; Richert, Clemens (Wiley, 2020-01-21)
    Studying nucleic acids often requires labeling. Many labeling approaches require covalent bonds between the nucleic acid and the label, which complicates experimental procedures. Noncovalent labeling avoids the need for highly specific reagents and ...
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    Screening and computational analysis of colorectal associated non-synonymous polymorphism in CTNNB1 gene in Pakistani population 
    Razak, Suhail; Bibi, Nousheen; Dar, Javid Ahmad; Afsar, Tayyaba; Almajwal, Ali; Parveen, Zahida; Jahan, Sarwat (Springer Science and Business Media LLC, 2019-11-07)
    Background: Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1) mutations, WNT signaling activation, tumor protein 53 (TP53) inactivation, BRAF, Adenomatous polyposis coli (APC) inactivation, KRAS, dysregulation ...
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    The Structural Dynamics of Sox2: Deciphering the Role of Intrinsically Disordered Regions in Pioneer Transcription Factors 
    Bjarnason, Sveinn (University of Iceland, School of Engineering and Natural Sciences, Faculty of Life and Environmental Sciences, 2024-05-10)
    Þessi ritgerð skoðar hlutverk ómótaðra próteina og svæða í kjarna heilkjörnunga, með áherslu á frumkvöðla umritunarþáttinn Sox2. Sox2 er þekkt fyrir hlutverk sitt í viðhaldi á fjölhæfni stofnfrumna og fyrir að hefja breytingar á tjáningu gena sem eru ...