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Browsing by Subject "Prótín"
Now showing items 1-18 of 18
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bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules (Royal Society of Chemistry (RSC), 2016)Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement ... -
(MDPI AG, 2017-11-17)Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine deamination of viral DNA and a not ...
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(2021-11)Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using ...
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(Public Library of Science (PLoS), 2019-07-29)Background Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-e4 allele has long been associated with increased risks of Alzheimer's disease and mortality, but the effect of the less prevalent ...
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(Jens Guðmundur Hjörleifsson, 2018-06-06)Protein quaternary structures are fundament for life. Proteins have evolved towards large assemblies of subunits needed for the execution of complex chemistry, for building structural components or for compartmentalization. Most oligomeric enzymes ...
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(University of Iceland, School of Engineering and Natural Sciences, Faculty of Physical Sciences, 2020-10)Life on earth is found everywhere where water is found, meaning that life has adapted to extremely varied environments. Thus, protein structures must adapt to a myriad of environmental stressors while maintaining their functional forms. In the case ...
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(Springer Nature, 2012-01-29)There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate ...
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(Ovid Technologies (Wolters Kluwer Health), 2017-04)Background Results from 2 cohort studies in Scotland established in the 1940s and 1950s (Aberdeen and Motherwell) suggested that a high protein diet during pregnancy might adversely influence offspring blood pressure at adult age. Our objective was to ...
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(2020-01-24)Interrupted dimeric coiled coil segments are found in a broad range of proteins and generally confer selective functional properties such as binding to specific ligands. However, there is only one documented case of a basic-helix-loop-helix leucine ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-01-10)The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to a larger family of basic helix-loop-helix leucine zipper transcription factors that are able to bind DNA and regulate gene expression. MITF is crucial for melanocyte development and has been ...
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(University of Iceland, School of Health Sciences, Faculty of Food Science and Nutrition, 2023-04)A significant amount of small pelagic species and side streams obtained from industrial fish processing are currently converted to fishmeal and fish oil, and primarily used in feed production. The demand for fish and seafood products and fishmeal ...
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(Elsevier BV, 2018-10)Pentraxins arefluid phase pattern recognition molecules that form an important part of the innate immunedefence and are conserved betweenfish and human. In Atlantic cod (Gadus morhuaL.), two pentraxin-likeproteins have been described, CRP-I and CRP-II. ...
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(Elsevier BV, 2019-03)Post-translational protein deimination is mediated by peptidylarginine deiminases (PADs), which are calcium dependent enzymes conserved throughout phylogeny with physiological and pathophysiological roles. Protein deimination occurs via the conversion ...
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(American Chemical Society (ACS), 2017-09-07)The effect of ionic strength on enzyme activity and stability varies considerably between enzymes. Ionic strength is known to affect the catalytic activity of some alkaline phosphatases (APs), such as Escherichia coli AP, but how ions affect APs is ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2018)Inngangur: Þegar kona verður þunguð, eiga sér stað miklar breytingar á æðakerfi hennar, til að mæta aukinni blóðþörf til fylgju og fósturs og tryggja eðlilegan vöxt fóstursins. Til að þetta sé hægt, þarf stækkun á æðum sem flytja blóð til fóstursins ...
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(Springer Science and Business Media LLC, 2019-11-14)The availability of engineered biological tissues holds great potential for both clinical applications and basic research in a life science laboratory. A prototype standalone perfusion/compression bioreactor system was proposed to address the osteogenic ...
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(Springer Science and Business Media LLC, 2020-01-23)Protein stability is a widely studied topic, there are still aspects however that need addressing. In this paper we examined the effects of multiple proline substitutions into loop regions of the kinetically stable proteinase K-like serine protease ...
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(American Chemical Society (ACS), 2018)A combination of two elements’ (Au, Zn) X-ray absorption spectroscopy (XAS) and time-dependent density functional theory (TD-DFT) allowed the elucidation of differential substitution pathways of Au(I) and Au(III) compounds reacting with biologically ...
Now showing items 1-18 of 18