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Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later

Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later


Titill: Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later
Höfundur: Hrolfsdottir, Laufey   orcid.org/0000-0003-1974-4205
Halldórsson, Þórhallur Ingi
Rytter, Dorte
Bech, Bodil Hammer
Birgisdottir, Bryndis Eva   orcid.org/0000-0002-5788-4551
Gunnarsdottir, Ingibjorg   orcid.org/0000-0001-9447-8627
Granström, Charlotta
Henriksen, Tine Brink
Olsen, Sjurdur F.
Maslova, Ekaterina
Útgáfa: 2017-04
Tungumál: Enska
Umfang: e005808
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Matvæla- og næringarfræðideild (HÍ)
Faculty of Food Science and Nutrition (UI)
Birtist í: Journal of the American Heart Association;6(4)
ISSN: 2047-9980
DOI: 10.1161/JAHA.117.005808
Efnisorð: Blood pressure; Macronutrient; Nutrition; Pregnancy; Protein; Young adults; Blóðþrýstingur; Mataræði; Meðganga; Prótín; Ungt fólk
URI: https://hdl.handle.net/20.500.11815/361

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Tilvitnun:

Hrolfsdottir, L., Halldorsson, T. I., Rytter, D., Bech, B. H., Birgisdottir, B. E., Gunnarsdottir, I., . . . Maslova, E. (2017). Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later. Journal of the American Heart Association, 6(4). doi:10.1161/jaha.117.005808

Útdráttur:

Background Results from 2 cohort studies in Scotland established in the 1940s and 1950s (Aberdeen and Motherwell) suggested that a high protein diet during pregnancy might adversely influence offspring blood pressure at adult age. Our objective was to examine this association in the Danish Fetal Origins Cohort (DaFO88). Methods and Results This was a prospective birth cohort of 965 women who gave birth in 1988–1989 in Aarhus, Denmark, and whose offspring (n=434) participated in a clinical examination ≈20 years later. Macronutrient intake was assessed in gestational week 30. Multivariable adjusted linear regression was used to examine the relation between higher maternal protein intake, at the expense of carbohydrates, and offspring blood pressure (isocaloric substitution). Main analyses were adjusted for mother's age during pregnancy, prepregnancy body mass index, parity, smoking during pregnancy, educational level, and offspring's sex. The mean total energy intake was 8.7 MJ/day (SD 2.3 MJ/day). The mean energy from carbohydrate, fat, and protein intake was 51, 31, and 16 of total energy, respectively. The results showed that after adjustment, higher maternal protein intake was associated with slightly higher offspring diastolic blood pressure (highest compared with the lowest quintile of protein intake: ∆=2.4 mm Hg; 95% CI 0.4–4.4; P=0.03 for trend). Similar differences, although not significant, were found for systolic blood pressure (∆=2.6 mm Hg; 95% CI −0.0 to 5.3; P=0.08 for trend). Conclusions Higher maternal dietary protein intake at the expense of carbohydrates was associated with a modest increase in offspring blood pressure in young adulthood.

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This is an open access article under the terms of the Creative Commons Attribution‐Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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