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Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Hrolfsdottir, Laufey
dc.contributor.author Halldorsson, Thorhallur
dc.contributor.author Rytter, Dorte
dc.contributor.author Bech, Bodil Hammer
dc.contributor.author Birgisdottir, Bryndis Eva
dc.contributor.author Gunnarsdottir, Ingibjorg
dc.contributor.author Granström, Charlotta
dc.contributor.author Henriksen, Tine Brink
dc.contributor.author Olsen, Sjurdur F.
dc.contributor.author Maslova, Ekaterina
dc.date.accessioned 2017-08-25T15:28:03Z
dc.date.available 2017-08-25T15:28:03Z
dc.date.issued 2017-04
dc.identifier.citation Hrolfsdottir, L., Halldorsson, T. I., Rytter, D., Bech, B. H., Birgisdottir, B. E., Gunnarsdottir, I., . . . Maslova, E. (2017). Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later. Journal of the American Heart Association, 6(4). doi:10.1161/jaha.117.005808
dc.identifier.issn 2047-9980
dc.identifier.uri https://hdl.handle.net/20.500.11815/361
dc.description.abstract Background Results from 2 cohort studies in Scotland established in the 1940s and 1950s (Aberdeen and Motherwell) suggested that a high protein diet during pregnancy might adversely influence offspring blood pressure at adult age. Our objective was to examine this association in the Danish Fetal Origins Cohort (DaFO88). Methods and Results This was a prospective birth cohort of 965 women who gave birth in 1988–1989 in Aarhus, Denmark, and whose offspring (n=434) participated in a clinical examination ≈20 years later. Macronutrient intake was assessed in gestational week 30. Multivariable adjusted linear regression was used to examine the relation between higher maternal protein intake, at the expense of carbohydrates, and offspring blood pressure (isocaloric substitution). Main analyses were adjusted for mother's age during pregnancy, prepregnancy body mass index, parity, smoking during pregnancy, educational level, and offspring's sex. The mean total energy intake was 8.7 MJ/day (SD 2.3 MJ/day). The mean energy from carbohydrate, fat, and protein intake was 51, 31, and 16 of total energy, respectively. The results showed that after adjustment, higher maternal protein intake was associated with slightly higher offspring diastolic blood pressure (highest compared with the lowest quintile of protein intake: ∆=2.4 mm Hg; 95% CI 0.4–4.4; P=0.03 for trend). Similar differences, although not significant, were found for systolic blood pressure (∆=2.6 mm Hg; 95% CI −0.0 to 5.3; P=0.08 for trend). Conclusions Higher maternal dietary protein intake at the expense of carbohydrates was associated with a modest increase in offspring blood pressure in young adulthood.
dc.description.sponsorship Danish Council for Strategic Research University of Iceland Research Fund
dc.format.extent e005808
dc.language.iso en
dc.publisher Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartofseries Journal of the American Heart Association;6(4)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Blood pressure
dc.subject Macronutrient
dc.subject Nutrition
dc.subject Pregnancy
dc.subject Protein
dc.subject Young adults
dc.subject Blóðþrýstingur
dc.subject Mataræði
dc.subject Meðganga
dc.subject Prótín
dc.subject Ungt fólk
dc.title Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the terms of the Creative Commons Attribution‐Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.description.version Peer Reviewed
dc.identifier.journal Journal of the American Heart Association
dc.identifier.doi 10.1161/JAHA.117.005808
dc.relation.url https://syndication.highwire.org/content/doi/10.1161/JAHA.117.005808
dc.contributor.department Matvæla- og næringarfræðideild (HÍ)
dc.contributor.department Faculty of Food Science and Nutrition (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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