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bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

Title: bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules
Author: Jagtap, Anil P.
Geiger, Michel-Andreas
Stöppler, Daniel
Orwick-Rydmark, Marcella
Oschkinat, Hartmut
Sigurdsson, Snorri   orcid.org/0000-0003-2492-1456
Date: 2016
Language: English
Scope: 7020-7023
University/Institute: Háskóli Íslands
University of Iceland
School: Verkfræði- og náttúruvísindasvið (HÍ)
School of Engineering and Natural Sciences (UI)
Department: Raunvísindadeild (HÍ)
Faculty of Physical Sciences (UI)
Raunvísindastofnun (HÍ)
Science Institute (UI)
Series: Chemical Communications;52(43)
ISSN: 1359-7345
1364-548X (eISSN)
DOI: 10.1039/C6CC01813K
Subject: Angle spinning NMR; Solid state; Nitroxide biradicals; Magnetic resonance; Amyloid fibrils; Protein; Resolution; Spectroscopy; Agents; Litrófsgreining; Segulmagn; Prótín; Kjarnsýrur
URI: https://hdl.handle.net/20.500.11815/1959

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Citation:

Jagtap, A. P., Geiger, M. -A., Stöppler, D., Orwick-Rydmark, M., Oschkinat, H., & Sigurdsson, S. T. (2016). BcTol: A highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules. Chemical Communications, 52(43), 7020-7023. doi:10.1039/c6cc01813k

Abstract:

Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.

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