bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

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Royal Society of Chemistry (RSC)

Úrdráttur

Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.

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Post-print (lokagerð höfundar)

Efnisorð

Angle spinning NMR, Solid state, Nitroxide biradicals, Magnetic resonance, Amyloid fibrils, Protein, Resolution, Spectroscopy, Agents, Litrófsgreining, Segulmagn, Prótín, Kjarnsýrur

Citation

Jagtap, A. P., Geiger, M. -A., Stöppler, D., Orwick-Rydmark, M., Oschkinat, H., & Sigurdsson, S. T. (2016). BcTol: A highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules. Chemical Communications, 52(43), 7020-7023. doi:10.1039/c6cc01813k

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