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Fletta eftir deild "Læknadeild (HÍ)"

Fletta eftir deild "Læknadeild (HÍ)"

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    Body silhouettes as a tool to reflect obesity in the past 
    Lønnebotn, Marianne; Svanes, Cecilie; Igland, Jannicke; Franklin, Karl A.; Accordini, Simone; Benediktsdóttir, Bryndís; Bentouhami, Hayat; Blanco, José A. G.; Bono, Roberto; Corsico, Angelo; Demoly, Pascal; Dharmage, Shyamali; Dorado Arenas, Sandra; Garcia, Judith; Heinrich, Joachim; Holm, Mathias; Janson, Christer; Jarvis, Debbie; Leynaert, Bénédicte; Martinez-Moratalla, Jesús; Nowak, Dennis; Pin, Isabelle; Raherison-Semjen, Chantal; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Skulstad, Svein Magne; Dratva, Julia; Gómez Real, Francisco (Public Library of Science (PLoS), 2018-04-25)
    Life course data on obesity may enrich the quality of epidemiologic studies analysing health consequences of obesity. However, achieving such data may require substantial resources. We investigated the use of body silhouettes in adults as a tool to ...
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    BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export 
    Ngeow, Kao Chin; Friedrichsen, Hans J.; Li, Linxin; Zeng, Zhiqiang; Andrews, Sarah; Volpon, Laurent; Brunsdon, Hannah; Berridge, Georgina; Picaud, Sarah; Fischer, Roman; Lisle, Richard; Knapp, Stefan; Filippakopoulos, Panagis; Knowles, Helen; Steingrimsson, Eirikur; Borden, Katherine L. B.; Patton, E. Elizabeth; Goding, Colin R. (Proceedings of the National Academy of Sciences, 2018-08-27)
    The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective ...
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    Brátt hjartadrep á Íslandi í fertugum og yngri 2005-2009. Samanburður við tímabilið 1980-1984 
    Magnússon, Björn Jakob; Agnarsson, Uggi; Gudnason, Thorarinn; Thorgeirsson, Gudmundur (Læknafélag Íslands / Icelandic Medical Association, 2017-01-05)
    Inngangur: Þótt brátt hjartadrep sé fyrst og fremst sjúkdómur eldra fólks getur það valdið ótímabærum dauða, heilsubresti og skertum lífsgæðum hjá yngra fólki. Árin 1980-1984 voru nýgengi, áhættuþættir, staðsetning hjartadreps, ástand kransæða og ...
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    The BRCA1 c.4096+3A>G Variant Displays Classical Characteristics of Pathogenic BRCA1 Mutations in Hereditary Breast and Ovarian Cancers, But Still Allows Homozygous Viability 
    Arason, Adalgeir; Agnarsson, Bjarni A.; Jóhannesdóttir, Gudrún; Jóhannsson, Óskar Þór; Hilmarsdóttir, Bylgja; Reynisdóttir, Inga; Barkardottir, Rosa Bjork (MDPI AG, 2019-11-01)
    Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ...
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    Burden of rotavirus disease in young children in Iceland – Time to vaccinate? 
    Kristinsdottir, Iris; Haraldsson, Asgeir; Löve, Arthur; Asgeirsdottir, Tinna Laufey; Thors, Valtyr (Elsevier, 2021-08-09)
    Background: Acute gastroenteritis poses a significant burden on young children, families, health care facilities and societies. Rotavirus is the most common pathogen, but rotavirus infections are vaccine preventable. Information on the epidemiology of ...
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    A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making 
    Ågerstrand, Marlene; Christiansen, Sofie; Hanberg, Annika; Rudén, Christina; Andersson, Lars; Andersen, Sjur; Appelgren, Henrik; Bjørge, Christine; Clausen, Ian Henning; Eide, Dag Markus; Hartmann, Nanna B.; Husøy, Trine; Halldórsson, Halldór Pálmar; van der Hagen, Marianne; Ingre-Khans, Ellen; Lillicrap, Adam David; Beltoft, Vibe Meister; Mörk, Anna-Karin; Murtomaa-Hautala, Mari; Nielsen, Elsa; Ólafsdóttir, Kristín; Palomäki, Jaana; Papponen, Hinni; Reiler, Emilie Marie; Stockmann-Juvala, Helene; Suutari, Tiina; Tyle, Henrik; Beronius, Anna (Wiley, 2018-01-03)
    This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer‐reviewed research studies in regulatory decision‐making. Moreover, this ...
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    Can a Simple Dietary Screening in Early Pregnancy Identify Dietary Habits Associated with Gestational Diabetes? 
    Hrolfsdottir, Laufey; Gunnarsdottir, Ingibjorg; Birgisdottir, Bryndis Eva; Hreiðarsdóttir, Ingibjörg Th.; Smárason, Alexander; Hardardottir, Hildur; Halldorsson, Thorhallur (MDPI AG, 2019-08-11)
    Gestational diabetes mellitus (GDM) is predominantly a lifestyle disease, with diet being an important modifiable risk factor. A major obstacle for the prevention in clinical practice is the complexity of assessing diet. In a cohort of 1651 Icelandic ...
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    Can postoperative dexamethasone nanoparticle eye drops replace mitomycin C in trabeculectomy? 
    Johannesson, Gauti; Gottfredsdottir, Maria; Ásgrimsdóttir, Guðrún Marta; Loftsson, Thorsteinn; Stefánsson, Einar (Wiley, 2020-02-17)
    Purpose: Compare (a) nonmitomycin C (MMC) trabeculectomy and 1.5% dexamethasone nanoparticle (DexNP) eye drops postoperatively with (b) trabeculectomy with MMC and Maxidex® eye drops postoperatively. Methods: Randomized prospective single masked clinical ...
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    Can ultrasound on admission in active labor predict labor duration and a spontaneous delivery? 
    Hjartardóttir, Hulda; Lund, Sigrún Helga; Benediktsdottir, Sigurlaug; Geirsson, Reynir; Eggebø, Torbjørn M. (Elsevier BV, 2021-04)
    Background Identifying predictive factors for a normal outcome at admission in the labor ward would be of value for planning labor care, timing interventions and in preventing labor dystocia. Clinical assessments of fetal head station and position ...
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    Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries 
    Tao, Wenjing; Santoni, Giola; von Euler-Chelpin, My; Ljung, Rickard; Lynge, Elsebeth; Pukkala, Eero; Ness-Jensen, Eivind; Romundstad, Pål; Tryggvadottir, Laufey; Lagergren, Jesper (Springer Science and Business Media LLC, 2020-06-13)
    Purpose: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national ...
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    Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries 
    Eysteinsson, Thor; Guðmundsdóttir, Hrönn; Harðarson, Arnar Össur; Berrino, Emanuela; Selleri, Silvia; Supuran, Claudiu; carta, fabrizio (MDPI AG, 2019-01-22)
    Carbonic anhydrase inhibitors (CAIs), such as dorzolamide (DZA), are used as anti-glaucoma drugs to lower intraocular pressure, but it has been found that some of these drugs act as vasodilators of retinal arteries. The exact mechanism behind the ...
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    Cardiac Rehabilitation Availability and Density around the Globe 
    Turk-Adawi, Karam; Supervia, Marta; Lopez-Jimenez, Francisco; Pesah, Ella; Ding, Rongjing; Britto, Raquel R.; Bjarnason-Wehrens, Birna; Derman, Wayne; Abreu, Ana; Babu, Abraham S.; Santos, Claudia Anchique; Jong, Seng Khiong; Cuenza, Lucky; Yeo, Tee Joo; Scantlebury, Dawn; Andersen, Karl; Gonzalez, Graciela; Giga, Vojislav; Vulic, Dusko; Vataman, Eleonora; Cliff, Jacqueline; Kouidi, Evangelia; Yagci, Ilker; Kim, Chul; Benaim, Briseida; Estany, Eduardo Rivas; Fernandez, Rosalia; Radi, Basuni; Gaita, Dan; Simon, Attila; Chen, Ssu-Yuan; Roxburgh, Brendon; Martin, Juan Castillo; Maskhulia, Lela; Burdiat, Gerard; Salmon, Richard; Lomelí, Hermes; Sadeghi, Masoumeh; Sovova, Eliska; Hautala, Arto; Tamuleviciute-Prasciene, Egle; Ambrosetti, Marco; Neubeck, Lis; Asher, Elad; Kemps, Hareld; Eysymontt, Zbigniew; Farsky, Stefan; Hayward, Jo; Prescott, Eva; Dawkes, Susan; Santibanez, Claudio; Zeballos, Cecilia; Pavy, Bruno; Kiessling, Anna; Sarrafzadegan, Nizal; Baer, Carolyn; Thomas, Randal; Hu, Dayi; Grace, Sherry L. (Elsevier BV, 2019-08)
    Background: Despite the epidemic of cardiovascular disease and the benefits of cardiac rehabilitation (CR), availability is known to be insufficient, although this is not quantified. This study ascertained CR availability, volumes and its drivers, and ...
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    Cell Internalization in Fluidic Culture Conditions Is Improved When Microparticles Are Specifically Targeted to the Human Epidermal Growth Factor Receptor 2 (HER2) 
    Mora-Espí, Inmaculada; Ibáñez, Elena; Soriano, Jorge; Nogués, Carme; Gudjonsson, Thorarinn; Barrios, Leonardo (MDPI AG, 2019-04-11)
    Purpose: To determine if the specific targeting of microparticles improves their internalization by cells under fluidic conditions. Methods: Two isogenic breast epithelial cell lines, one overexpressing the Human Epidermal Growth Factor Receptor 2 ...
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    Change in the prevalence asthma, rhinitis and respiratory symptom over a 20 year period: associations to year of birth, life style and sleep related symptoms 
    Janson, Christer; Johannessen, Ane; Franklin, Karl; Svanes, Cecilie; Schiöler, Linus; Malinovschi, Andrei; Gislason, Thorarinn; Benediktsdóttir, Bryndís; Schlünssen, Vivi; Jõgi, Rain; Jarvis, Deborah; Lindberg, Eva (Springer Science and Business Media LLC, 2018-09-12)
    Background: The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related variables. Method: Adults 20-44 ...
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    Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum 
    Yi, Zhiqian; Su, Yixi; Xu, Maonian; Bergmann, Andreas; Ingþórsson, Sævar; Rolfsson, Óttar; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur; Fu, Weiqi (MDPI AG, 2018-08-04)
    Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain performance for high product yields towards commercialization. In this study, we generated a ...
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    Choosing wisely? Quantifying the extent of three low value psychotropic prescribing practices in Australia 
    Brett, Jonathan; Zoega, Helga; Buckley, Nicholas A.; Daniels, Benjamin J.; Elshaug, Adam G.; Pearson, Sallie-Anne (Springer Nature, 2018-12)
    Background The global Choosing Wisely campaign has identified the following psychotropic prescribing as low-value (harmful or wasteful): (1) benzodiazepine use in the elderly, (2) antipsychotic use in dementia and (3) prescribing two or more antipsychotics ...
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    The circular RNome of primary breast cancer 
    Smid, Marcel; Wilting, Saskia M.; Uhr, Katharina; Rodríguez-González, F. Germán; de Weerd, Vanja; Prager-Van der Smissen, Wendy J.C.; van der Vlugt-Daane, Michelle; van Galen, Anne; Nik-Zainal, Serena; Butler, Adam; Martin, Sancha; Davies, Helen R.; Staaf, Johan; van de Vijver, Marc J.; Richardson, Andrea L.; MacGrogan, Gaëten; Salgado, Roberto; van den Eynden, Gert G.G.M.; Purdie, Colin A.; Thompson, Alastair M.; Caldas, Carlos; Span, Paul N.; Sweep, Fred C.G.J.; Simpson, Peter T.; Lakhani, Sunil R.; Van Laere, Steven; Desmedt, Christine; Paradiso, Angelo; Eyfjörð, Jórunn Erla; Broeks, Annegien; Vincent-Salomon, Anne; Futreal, Andrew P.; Knappskog, Stian; King, Tari; Viari, Alain; Børresen-Dale, Anne-Lise; Stunnenberg, Hendrik G.; Stratton, Mike; Foekens, John A.; Sieuwerts, Anieta M.; Martens, John W.M. (Cold Spring Harbor Laboratory, 2019-01-28)
    Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped ...
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    A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe 
    Christensen, Stine Holmegaard; Timm, Signe; Janson, Christer; Benediktsdóttir, Bryndís; Forsberg, Bertil; Holm, Mathias; Jogi, Rain; Johannessen, Ane; Omenaas, Ernst; Sigsgaard, Torben; Svanes, Cecilie; Schlünssen, Vivi (Informa UK Limited, 2016-01)
    Background: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the ...
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    Clinical decision support system for the management of osteoporosis compared to NOGG guidelines and an osteology specialist: a validation pilot study 
    Guðmundsson, Haukur Týr; Hansen, Karen E.; Halldórsson, Bjarni; Ludviksson, Bjorn; Gudbjornsson, Bjorn (Springer Science and Business Media LLC, 2019-02-01)
    Background: Although osteoporosis is an easily diagnosed and treatable condition, many individuals remain untreated. Clinical decision support systems might increase appropriate treatment of osteoporosis. We designed the Osteoporosis Advisor (OPAD), a ...
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    Coexpression patterns define epigenetic regulators associated with neurological dysfunction 
    Boukas, Leandros; Havrilla, James M.; Hickey, Peter F.; Quinlan, Aaron R.; Bjornsson, Hans; Hansen, Kasper D. (Cold Spring Harbor Laboratory, 2019-03-11)
    Coding variants in epigenetic regulators are emerging as causes of neurological dysfunction and cancer. However, a comprehensive effort to identify disease candidates within the human epigenetic machinery (EM) has not been performed; it is unclear ...