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A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe

A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe


Titill: A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe
Höfundur: Christensen, Stine Holmegaard
Timm, Signe
Janson, Christer
Benediktsdóttir, Bryndís
Forsberg, Bertil
Holm, Mathias
Jogi, Rain
Johannessen, Ane
Omenaas, Ernst
Sigsgaard, Torben
... 2 fleiri höfundar Sýna alla höfunda
Útgáfa: 2016-01
Tungumál: Enska
Umfang: 33463
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: European Clinical Respiratory Journal;3(1)
ISSN: 2001-8525
DOI: 10.3402/ecrj.v3.33463
Efnisorð: Allergic rhinitis; Microbial diversity; Microbial exposure; Nasal symptoms; Pets; Place of upbringing; Ofnæmi; Kvef; Nefsjúkdómar; Gæludýr
URI: https://hdl.handle.net/20.500.11815/415

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Tilvitnun:

Christensen, S. H., Timm, S., Janson, C., Benediktsdóttir, B., Forsberg, B., Holm, M., . . . Schlünssen, V. (2016). A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe. European Clinical Respiratory Journal, 3(1), 33463. doi:10.3402/ecrj.v3.33463

Útdráttur:

Background: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood. Methods: The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 19451973. This paper analyses 13,376 participants of the third study wave. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models. Results: Livestock farm upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.540.85] and nasal symptoms (OR 0.82, 0.680.99) than city upbringing, and an urbanrural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.880.94). Pets in the home at birth (OR 0.78, 0.680.88) and during childhood (OR 0.83, 0.740.93) were associated with less subsequent allergic rhinitis. Pet keeping did not explain the protective effect of place of upbringing. Conclusion: Risk of allergic rhinitis and nasal symptoms in adulthood was inversely associated with the level of urbanisation during upbringing. Pets at birth decreased the risk further, but did not explain the urban rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findin

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This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

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