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Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries

Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries

Title: Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries
Author: Tao, Wenjing
Santoni, Giola
von Euler-Chelpin, My
Ljung, Rickard
Lynge, Elsebeth
Pukkala, Eero
Ness-Jensen, Eivind
Romundstad, Pål
Tryggvadottir, Laufey   orcid.org/0000-0001-8067-9030
Lagergren, Jesper
Date: 2020-06-13
Language: English
Scope: 3761-3767
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Obesity Surgery;30(10)
ISSN: 0960-8923
1708-0428 (eISSN)
DOI: 10.1007/s11695-020-04751-6
Subject: Metabolic surgery; Neoplasm; Obesity; Registries; Scandinavian and Nordic countries; Offita; Skurðlækningar; Krabbamein
URI: https://hdl.handle.net/20.500.11815/2190

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Tao, W., Santoni, G., von Euler-Chelpin, M. et al. Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries. Obesity Surgery 30, 3761–3767 (2020). https://doi.org/10.1007/s11695-020-04751-6


Purpose: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. Materials and Methods: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. Results: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). Conclusion: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.


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