Opin vísindi

Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Tao, Wenjing
dc.contributor.author Santoni, Giola
dc.contributor.author von Euler-Chelpin, My
dc.contributor.author Ljung, Rickard
dc.contributor.author Lynge, Elsebeth
dc.contributor.author Pukkala, Eero
dc.contributor.author Ness-Jensen, Eivind
dc.contributor.author Romundstad, Pål
dc.contributor.author Tryggvadottir, Laufey
dc.contributor.author Lagergren, Jesper
dc.date.accessioned 2020-11-09T15:16:06Z
dc.date.available 2020-11-09T15:16:06Z
dc.date.issued 2020-06-13
dc.identifier.citation Tao, W., Santoni, G., von Euler-Chelpin, M. et al. Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries. Obesity Surgery 30, 3761–3767 (2020). https://doi.org/10.1007/s11695-020-04751-6
dc.identifier.issn 0960-8923
dc.identifier.issn 1708-0428 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/2190
dc.description Publisher's version (útgefin grein)
dc.description.abstract Purpose: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. Materials and Methods: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. Results: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). Conclusion: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women.
dc.description.sponsorship Open access funding provided by Karolinska Institute. This work was supported by the Nordic Cancer Union [grant number 154860], the Swedish Cancer Society [grant number 14 0322], and the Swedish Research Council [D0547801].
dc.format.extent 3761-3767
dc.language.iso en
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Obesity Surgery;30(10)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Metabolic surgery
dc.subject Neoplasm
dc.subject Obesity
dc.subject Registries
dc.subject Scandinavian and Nordic countries
dc.subject Offita
dc.subject Skurðlækningar
dc.subject Krabbamein
dc.title Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries
dc.type info:eu-repo/semantics/article
dcterms.license Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version Peer Reviewed
dc.identifier.journal Obesity Surgery
dc.identifier.doi 10.1007/s11695-020-04751-6
dc.relation.url https://link.springer.com/article/10.1007/s11695-020-04751-6
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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