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Fletta eftir deild "Clinical Laboratory Services, Diagnostics and Blood Bank"

Fletta eftir deild "Clinical Laboratory Services, Diagnostics and Blood Bank"

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    Acetylsalicylic acid use is associated with improved survival in bacteremic pneumococcal pneumonia : A long-term nationwide study 
    Rögnvaldsson, Kristján Godsk; Bjarnason, Agnar; Kristinsson, Karl Gústaf; Bragason, Hörður T; Erlendsdóttir, Helga; Þorgeirsson, Guðmundur; Gottfreðsson, Magnús (2022-08)
    BACKGROUND: Pneumonia is commonly caused by Streptococcus pneumoniae (pneumococcus) and associated with subsequent cardiovascular complications and increased mortality. Potential short-term survival benefits conferred by acetylsalicylic acid (ASA) use ...
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    The adjuvants dmLT and mmCT enhance humoral immune responses to a pneumococcal conjugate vaccine after both parenteral or mucosal immunization of neonatal mice 
    Molina Estupiñan, Jenny Lorena; Pind, Auður Anna Aradóttir; Pajoohian, Poorya Foroutan; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2023-01-20)
    Immaturity of the neonatal immune system contributes to increased susceptibility to infectious diseases and poor vaccine responses. Therefore, better strategies for early life vaccination are needed. Adjuvants can enhance the magnitude and duration of ...
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    Aminopeptidase expression in multiple myeloma associates with disease progression and sensitivity to melflufen 
    Miettinen, Juho J.; Kumari, Romika; Traustadóttir, Gunnhildur Ásta; Huppunen, Maiju Emilia; Sergeev, Philipp; Majumder, Muntasir M.; Schepsky, Alexander; Guðjónsson, Þórarinn; Lievonen, Juha; Bazou, Despina; Dowling, Paul; O‘gorman, Peter; Slipicevic, Ana; Anttila, Pekka; Silvennoinen, Raija; Nupponen, Nina N.; Lehmann, Fredrik; Heckman, Caroline A. (2021-03-26)
    Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or ...
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    Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer 
    Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
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    Assessing thyroid cancer risk using polygenic risk scores 
    Liyanarachchi, Sandya; Gudmundsson, Julius; Ferkingstad, Egil; He, Huiling; Jónasson, Jón Gunnlaugur; Tragante, Vinicius; Asselbergs, Folkert W.; Xu, Li; Kiemeney, Lambertus A.; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hjartarson, Hannes; Hrafnkelsson, Jón; Sturgis, Erich M.; Brock, Pamela; Nabhan, Fadi; Thorleifsson, Gudmar; Ringel, Matthew D.; Stefansson, Kari; de la Chapelle, Albert (2020-03-17)
    Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed ...
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    Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016 
    on behalf of The Euro-GASP Network (2021-03-18)
    BACKGROUND: The emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, nationally and internationally, is a serious threat to the management and control of gonorrhoea. Limited and conflicting data regarding the epidemiological ...
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    Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis 
    Burden of AMR Collaborative Group (2019-01)
    Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by ...
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    Automated Cancer Diagnostics via Analysis of Optical and Chemical Images by Deep and Shallow Learning 
    Ísberg, Ólöf Gerður; Giunchiglia, Valentina; McKenzie, James S.; Takats, Zoltan; Jónasson, Jón Gunnlaugur; Bodvarsdottir, Sigridur Klara; Þorsteinsdóttir, Margrét; Xiang, Yuchen (2022-05-18)
    Optical microscopy has long been the gold standard to analyse tissue samples for the diagnostics of various diseases, such as cancer. The current diagnostic workflow is time-consuming and labour-intensive, and manual annotation by a qualified pathologist ...
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    The BLIMP1—EZH2 nexus in a non-Hodgkin lymphoma 
    Harðardóttir, Ingibjörg; Anderson, Kimberley Jade; Ósvaldsdóttir, Árný Björg; Atzinger, Birgit; Traustadóttir, Gunnhildur Ásta; Jensen, Kirstine Nolling; Lárusdóttir, Aðalheiður Elín; Bergþórsson, Jón Þór; Magnúsdóttir, Erna (2020-07-09)
    Waldenström’s macroglobulinemia (WM) is a non-Hodgkin lymphoma, resulting in antibody-secreting lymphoplasmacytic cells in the bone marrow and pathologies resulting from high levels of monoclonal immunoglobulin M (IgM) in the blood. Despite the key ...
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    Brca1 promoter methylation status in 1031 primary breast cancers predicts favorable outcomes following chemotherapy 
    Stefánsson, Ólafur A.; Hilmarsdóttir, Hólmfridur; Ólafsdóttir, Kristrún; Tryggvadóttir, Laufey; Sverrisdóttir, Ásgerdur; Jóhannsson, Óskar Þór; Jónasson, Jón Gunnlaugur; Eyfjörð, Jórunn Erla; Sigurdsson, Stefán Þórarinn (2019-12-11)
    Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
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    Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status 
    Olafsdottir, Elinborg J.; Borg, Ake; Jensen, Maj Britt; Gerdes, Anne Marie; Johansson, Anna L.V.; Barkardottir, Rosa B.; Johannsson, Oskar T.; Ejlertsen, Bent; Sønderstrup, Ida Marie Heeholm; Hovig, Eivind; Lænkholm, Anne Vibeke; Hansen, Thomas van Overeem; Olafsdottir, Gudridur H.; Rossing, Maria; Jonasson, Jon G.; Sigurdsson, Stefan; Loman, Niklas; Nilsson, Martin P.; Narod, Steven A.; Tryggvadottir, Laufey (2020-11-24)
    Background: The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was a negative prognostic factor. We sought to identify factors that predicted survival after ...
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    Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation 
    Ingþórsson, Sævar; Traustadóttir, Gunnhildur Ásta; Guðjónsson, Þórarinn (2022-10-24)
    The human breast gland is a unique organ as most of its development occurs postnatally between menarche and menopause, a period ranging from 30 to 40 years. During this period, the monthly menstruation cycle drives the mammary gland through phases of ...
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    Changes in invasive pneumococcal disease caused by streptococcus pneumoniae serotype 1 following introduction of pcv10 and pcv13 : Findings from the pserenade project 
    PSERENADE Team (2021-03-27)
    Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococ-cal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) con-taining ST1 antigen. The Pneumococcal Serotype Replacement and ...
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    Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative : a prospective analysis of surveillance data 
    Brueggemann, Angela B.; Jansen van Rensburg, Melissa J.; Shaw, David; McCarthy, Noel D.; Jolley, Keith A.; Maiden, Martin C.J.; van der Linden, Mark P.G.; Amin-Chowdhury, Zahin; Bennett, Désirée E.; Borrow, Ray; Brandileone, Maria Cristina C.; Broughton, Karen; Campbell, Ruth; Cao, Bin; Casanova, Carlo; Choi, Eun Hwa; Chu, Yiu Wai; Clark, Stephen A.; Claus, Heike; Coelho, Juliana; Corcoran, Mary; Cottrell, Simon; Cunney, Robert J.; Dalby, Tine; Davies, Heather; de Gouveia, Linda; Deghmane, Ala Eddine; Demczuk, Walter; Desmet, Stefanie; Drew, Richard J.; du Plessis, Mignon; Erlendsdóttir, Helga; Fry, Norman K.; Fuursted, Kurt; Gray, Steve J.; Henriques-Normark, Birgitta; Hale, Thomas; Hilty, Markus; Hoffmann, Steen; Humphreys, Hilary; Ip, Margaret; Jacobsson, Susanne; Johnston, Jillian; Kozakova, Jana; Kristinsson, Karl Gústaf; Krizova, Pavla; Kuch, Alicja; Ladhani, Shamez N.; Lâm, Thiên Trí; Lebedova, Vera; Lindholm, Laura; Litt, David J.; Martin, Irene; Martiny, Delphine; Mattheus, Wesley; McElligott, Martha; Meehan, Mary; Meiring, Susan; Mölling, Paula; Morfeldt, Eva; Morgan, Julie; Mulhall, Robert M.; Muñoz-Almagro, Carmen; Murdoch, David R.; Murphy, Joy; Musilek, Martin; Mzabi, Alexandre; Perez-Argüello, Amaresh; Perrin, Monique; Perry, Malorie; Redin, Alba; Roberts, Richard; Roberts, Maria; Rokney, Assaf; Ron, Merav; Scott, Kevin J.; Sheppard, Carmen L.; Siira, Lotta; Skoczyńska, Anna; Sloan, Monica; Slotved, Hans Christian; Smith, Andrew J.; Song, Joon Young; Taha, Muhamed Kheir; Toropainen, Maija; Tsang, Dominic; Vainio, Anni; van Sorge, Nina M.; Varon, Emmanuelle; Vlach, Jiri; Vogel, Ulrich; Vohrnova, Sandra; von Gottberg, Anne; Zanella, Rosemeire C.; Zhou, Fei (2021-06)
    Background: Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, are leading causes of invasive diseases, including bacteraemic pneumonia and meningitis, and of secondary ...
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    Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines : randomized controlled clinical trials conducted by the BIOVACSAFE consortium 
    Weiner, January; Lewis, David J.M.; Maertzdorf, Jeroen; Mollenkopf, Hans Joachim; Bodinham, Caroline; Pizzoferro, Kat; Linley, Catherine; Greenwood, Aldona; Mantovani, Alberto; Bottazzi, Barbara; Denoel, Philippe; Leroux-Roels, Geert; Kester, Kent E.; Jonsdottir, Ingileif; van den Berg, Robert; Kaufmann, Stefan H.E.; Del Giudice, Giuseppe (2019-12-01)
    Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpatient clinical studies (NCT01765413/NCT017 ...
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    Chlamydia trachomatis in iceland : Prevalence, clinico-epidemiological features and comparison of cobas 480 ct/ng and aptima combo 2 (ct/ng) for diagnosis 
    Hilmarsdóttir, Ingibjörg; Arnardóttir, Eva Mjöll; Jóhannesdóttir, Elísabet Reykdal; Golparian, Daniel; Unemo, Magnus (2021-02)
    The aims of this study were to assess the prevalence of, and risk factors for, Chlamydia trachomatis in at-tendees recruited prospectively from October 2018 to January 2019 at the only sexually transmitted infections clinic in Iceland (in Reykjavík), ...
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    A comparative study of adjuvants effects on neonatal plasma cell survival niche in bone marrow and persistence of humoral immune responses 
    Pind, Auður Anna Aradóttir; Thorsdottir, Sigrun; Magnusdottir, Gudbjorg Julia; Meinke, Andreas; Del Giudice, Giuseppe; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2022-08-03)
    The neonatal immune system is distinct from the immune system of older individuals rendering neonates vulnerable to infections and poor responders to vaccination. Adjuvants can be used as tools to enhance immune responses to co-administered antigens. ...
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    Comparison of medication adherence to different oral anticoagulants : population-based cohort study 
    Ingason, Arnar Bragi; Hreinsson, Jóhann P.; Lund, Sigrún Helga; Ágústsson, Arnar Snær; Rumba, Edward; Pálsson, Daníel; Reynisson, Indriði E.; Guðmundsdóttir, Brynja R; Önundarson, Páll Torfi; Björnsson, Einar Stefán (2023-01-01)
    OBJECTIVE: Previous observational studies have yielded conflicting results on whether medication adherence differs between patients receiving warfarin and direct oral anticoagulants (DOACs). Importantly, no study has adequately accounted for warfarin ...
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    Comparison of the effectiveness and safety of direct oral anticoagulants : a nationwide propensity score–weighted study 
    Ingason, Arnar Bragi; Hreinsson, Johann Pall; Agustsson, Arnar Snaer; Lund, Sigrun Helga; Rumba, Edward; Palsson, Daniel Alexander; Reynisson, Indridi Einar; Guðmundsdóttir, Brynja R; Önundarson, Páll Torfi; Björnsson, Einar Stefán (2022-12-23)
    In the pivotal randomized controlled trials (RCTs) for patients with atrial fibrillation, direct oral anticoagulants (DOACs) had similar or even superior efficacy and safety compared with warfarin. However, RCTs comparing different DOACs are nonexistent ...
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    The complexity of kidney disease and diagnosing it - cystatin C, selective glomerular hypofiltration syndromes and proteome regulation 
    Malmgren, Linnea; Öberg, Carl; den Bakker, Emil; Leion, Felicia; Siódmiak, Joanna; Åkesson, Anna; Lindström, Veronica; Herou, Erik; Dardashti, Alain; Xhakollari, Liana; Grubb, Gabriel; Strevens, Helena; Abrahamson, Magnus; Helmersson-Karlqvist, Johanna; Magnusson, Martin; Björk, Jonas; Nyman, Ulf; Ärnlöv, Johan; Ridefelt, Peter; Åkerfeldt, Torbjörn; Hansson, Magnus; Sjöström, Anna; Mårtensson, Johan; Itoh, Yoshihisa; Grubb, David; Tenstad, Olav; Hansson, Lars-Olov; Ólafsson, Ísleifur; Campos, Araceli Jarquin; Risch, Martin; Risch, Lorenz; Larsson, Anders; Nordin, Gunnar; Pottel, Hans; Christensson, Anders; Bjursten, Henrik; Bökenkamp, Arend; Grubb, Anders (2023-03)
    Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new ...