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Chlamydia trachomatis in iceland : Prevalence, clinico-epidemiological features and comparison of cobas 480 ct/ng and aptima combo 2 (ct/ng) for diagnosis

Chlamydia trachomatis in iceland : Prevalence, clinico-epidemiological features and comparison of cobas 480 ct/ng and aptima combo 2 (ct/ng) for diagnosis


Title: Chlamydia trachomatis in iceland : Prevalence, clinico-epidemiological features and comparison of cobas 480 ct/ng and aptima combo 2 (ct/ng) for diagnosis
Author: Hilmarsdóttir, Ingibjörg
Arnardóttir, Eva Mjöll
Jóhannesdóttir, Elísabet Reykdal
Golparian, Daniel
Unemo, Magnus
Date: 2021-02
Language: English
Scope: 6
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Medicine
Clinical Laboratory Services, Diagnostics and Blood Bank
Internal Medicine and Emergency Services
Series: Acta Dermato-Venereologica; 101(2)
ISSN: 0001-5555
DOI: https://doi.org/10.2340/00015555-3762
Subject: Kynsjúkdómar; Klamýdía; Ísland; Ísland; Áhættuþættir; Algengi sjúkdóma; Chlamydia trachomatis; Iceland; Neisseria gonorrhoeae; Nucleic acid amplification; Prevalence; Risk factor; Sexually transmitted disease; Chlamydia trachomatis/genetics; Chlamydia Infections/diagnosis; Humans; Male; Tomography, X-Ray Computed; Sensitivity and Specificity; Female; Gonorrhea/diagnosis; Iceland/epidemiology; Dermatology
URI: https://hdl.handle.net/20.500.11815/2921

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Citation:

Hilmarsdóttir , I , Arnardóttir , E M , Jóhannesdóttir , E R , Golparian , D & Unemo , M 2021 , ' Chlamydia trachomatis in iceland : Prevalence, clinico-epidemiological features and comparison of cobas 480 ct/ng and aptima combo 2 (ct/ng) for diagnosis ' , Acta Dermato-Venereologica , vol. 101 , no. 2 , adv00393 , pp. adv00393 . https://doi.org/10.2340/00015555-3762

Abstract:

The aims of this study were to assess the prevalence of, and risk factors for, Chlamydia trachomatis in at-tendees recruited prospectively from October 2018 to January 2019 at the only sexually transmitted infections clinic in Iceland (in Reykjavík), and to eva-luate the cobas 4800 CT/NG Test and Aptima Combo 2 Assay for C. trachomatis detection in male urine and female vaginal swabs. Prevalence of C. trachomatis was 15.8% among 487 women and 13.6% among 491 men (no Neisseria gonorrhoeae positive patients were found). C. trachomatis detection was independently and positively associated with being tested for contact tracing, 18–24 years of age, and reporting ≥ 6 sexual partners within 12 months. Reporting sex with non-residents of Iceland was associated with a lower risk of C. trachomatis infection. Both assays had a high sen-sitivity in detection of C. trachomatis (Aptima Combo 2: 100%; cobas 4800 CT/NG: 95.1%) and high speci-ficity (100% and 99.6%, respectively). The high local prevalence of C. trachomatis and increased acquisition risk following sex with residents are of public health concern.

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