Opin vísindi

A shared genetic contribution to breast cancer and schizophrenia

A shared genetic contribution to breast cancer and schizophrenia

Titill: A shared genetic contribution to breast cancer and schizophrenia
Höfundur: Lu, Donghao
Song, Jie
Lu, Yi
Fall, Katja
Chen, Xu
Fang, Fang
Landén, Mikael
Hultman, Christina M.
Czene, Kamila
Sullivan, Patrick
... 2 fleiri höfundar Sýna alla höfunda
Útgáfa: 2020-09-15
Tungumál: Enska
Umfang: 4637
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Nature Communications;11(1)
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18492-8
Efnisorð: Schizophrenia; Breast cancer; Phenotype; Geðklofi; Brjóstakrabbamein; Arfgengi; Erfðarannsóknir
URI: https://hdl.handle.net/20.500.11815/2131

Skoða fulla færslu

Tilvitnun:

Lu, D., Song, J., Lu, Y. et al. A shared genetic contribution to breast cancer and schizophrenia. Nat Commun 11, 4637 (2020). https://doi.org/10.1038/s41467-020-18492-8

Útdráttur:

An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.

Athugasemdir:

Publisher's version (útgefin grein)

Leyfi:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Skrár

Icon
Nafn: s41467-020-18492-8.pdf
Stærð: 1.030Mb
Skráartegund: PDF
Lýsing: Publisher´s version
Skoða/Opna

Þetta verk birtist í eftirfarandi safni/söfnum: