A shared genetic contribution to breast cancer and schizophrenia

Lu, Donghao; Song, Jie; Lu, Yi; Fall, Katja; Chen, Xu; Fang, Fang; Landén, Mikael; Hultman, Christina M.; Czene, Kamila; Sullivan, Patrick; Tamimi, Rulla M.; Valdimarsdottir, Unnur

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dc.contributor	Háskóli Íslands
dc.contributor	University of Iceland
dc.contributor.author	Lu, Donghao
dc.contributor.author	Song, Jie
dc.contributor.author	Lu, Yi
dc.contributor.author	Fall, Katja
dc.contributor.author	Chen, Xu
dc.contributor.author	Fang, Fang
dc.contributor.author	Landén, Mikael
dc.contributor.author	Hultman, Christina M.
dc.contributor.author	Czene, Kamila
dc.contributor.author	Sullivan, Patrick
dc.contributor.author	Tamimi, Rulla M.
dc.contributor.author	orcid.org/0000-0001-5382-946X Valdimarsdottir, Unnur
dc.date.accessioned	2020-10-22T10:46:45Z
dc.date.available	2020-10-22T10:46:45Z
dc.date.issued	2020-09-15
dc.identifier.citation	Lu, D., Song, J., Lu, Y. et al. A shared genetic contribution to breast cancer and schizophrenia. Nat Commun 11, 4637 (2020). https://doi.org/10.1038/s41467-020-18492-8
dc.identifier.issn	2041-1723
dc.identifier.uri	https://hdl.handle.net/20.500.11815/2131
dc.description	Publisher's version (útgefin grein)
dc.description.abstract	An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.
dc.description.sponsorship	This work is supported by the Swedish Research Council (grant number: 2018-00648, to D.L.), Karolinska Institutet Research Foundation (grant number: 2018-01585, to D.L.), Grant of Excellence, Icelandic Research Fund (grant number 163362-051, to U.A.V.), and ERC Consolidator Grant (StressGene, grant number:726413, to U.A.V.). We thank Dr. Agnar Helgason, Dr. Patrick Sulem, and Dr. Kári Stefánsson from deCODE Genetics, Iceland for helpful discussions on data analysis and interpretations. We also acknowledge the shared GWAS statistical summaries of schizophrenia from the Psychiatric Genetics Consortium and breast cancer from the Breast Cancer Association Consortium.
dc.format.extent	4637
dc.language.iso	en
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartofseries	Nature Communications;11(1)
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Schizophrenia
dc.subject	Breast cancer
dc.subject	Phenotype
dc.subject	Geðklofi
dc.subject	Brjóstakrabbamein
dc.subject	Arfgengi
dc.subject	Erfðarannsóknir
dc.title	A shared genetic contribution to breast cancer and schizophrenia
dc.type	info:eu-repo/semantics/article
dcterms.license	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.version	Peer Reviewed
dc.identifier.journal	Nature Communications
dc.identifier.doi	10.1038/s41467-020-18492-8
dc.relation.url	https://www.nature.com/articles/s41467-020-18492-8
dc.contributor.department	Læknadeild (HÍ)
dc.contributor.department	Faculty of Medicine (UI)
dc.contributor.school	Heilbrigðisvísindasvið (HÍ)
dc.contributor.school	School of Health Sciences (UI)