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A shared genetic contribution to breast cancer and schizophrenia

A shared genetic contribution to breast cancer and schizophrenia

Title: A shared genetic contribution to breast cancer and schizophrenia
Author: Lu, Donghao
Song, Jie
Lu, Yi
Fall, Katja
Chen, Xu
Fang, Fang
Landén, Mikael
Hultman, Christina M.
Czene, Kamila
Sullivan, Patrick
... 2 more authors Show all authors
Date: 2020-09-15
Language: English
Scope: 4637
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Nature Communications;11(1)
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18492-8
Subject: Schizophrenia; Breast cancer; Phenotype; Geðklofi; Brjóstakrabbamein; Arfgengi; Erfðarannsóknir
URI: https://hdl.handle.net/20.500.11815/2131

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Lu, D., Song, J., Lu, Y. et al. A shared genetic contribution to breast cancer and schizophrenia. Nat Commun 11, 4637 (2020). https://doi.org/10.1038/s41467-020-18492-8


An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.


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