Titill: | Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation |
Höfundur: |
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Útgáfa: | 2019-01-11 |
Tungumál: | Enska |
Umfang: | 229 |
Háskóli/Stofnun: | Háskóli Íslands University of Iceland |
Svið: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) |
Deild: | Lyfjafræðideild (HÍ) Faculty of Pharmaceutical Sciences (UI) |
Birtist í: | Materials;12(2) |
ISSN: | 1996-1944 |
DOI: | 10.3390/ma12020229 |
Efnisorð: | Aggregate; Complexation; Cyclodextrin; Nepafenac; Ocular drug delivery; Polymer; Self-assemble; Lyfjaefnafræði; Lyf; Augnsjúkdómar; Lyfhrifafræði; Sýklódextrín |
URI: | https://hdl.handle.net/20.500.11815/1855 |
Tilvitnun:Lorenzo-Veiga, B.; Sigurdsson, H.H.; Loftsson, T. Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation. Materials 2019, 12, 229.
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Útdráttur:The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of aggregates that are formed easily by self-assembly of cyclodextrin (CD)/drug complexes in aqueous solution. The aim of this study was to design a new eye drop formulation based on aggregates formed between CD/drug complexes. For this purpose, the physicochemical properties of the aggregates associated with six CDs and selected water-soluble polymers were analysed. Complex formation was studied using differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and 1 H nuclear magnetic resonance spectroscopy ( 1 H-NMR). Results showed that HPβCD performed best in terms of solubilization, while γ CD performed best in terms of enhancing nanoaggregate formation. Formation of inclusion complexes was confirmed by DSC, FT-IR and 1 H-NMR studies. A mixture of 15% (w/v) γ CD and 8% (w/v) HPβCD was selected for formulation studies. It was concluded that formulations with aggregate sizes less than 1 μm and viscosity around 10-19 centipoises can be easily prepared using a mixture of CDs. Formulations containing polymeric drug/CD nanoaggregates represent an interesting strategy for enhanced topical delivery of nepafenac.
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Athugasemdir:Publisher's version (útgefin grein)
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Leyfi:This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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