dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Lorenzo Veiga, Blanca |
dc.contributor.author |
Sigurdsson, Hakon Hrafn |
dc.contributor.author |
Loftsson, Thorsteinn |
dc.date.accessioned |
2020-05-28T11:12:38Z |
dc.date.available |
2020-05-28T11:12:38Z |
dc.date.issued |
2019-01-11 |
dc.identifier.citation |
Lorenzo-Veiga, B.; Sigurdsson, H.H.; Loftsson, T. Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation. Materials 2019, 12, 229. |
dc.identifier.issn |
1996-1944 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1855 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of aggregates that are formed easily by self-assembly of cyclodextrin (CD)/drug complexes in aqueous solution. The aim of this study was to design a new eye drop formulation based on aggregates formed between CD/drug complexes. For this purpose, the physicochemical properties of the aggregates associated with six CDs and selected water-soluble polymers were analysed. Complex formation was studied using differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and 1 H nuclear magnetic resonance spectroscopy ( 1 H-NMR). Results showed that HPβCD performed best in terms of solubilization, while γ CD performed best in terms of enhancing nanoaggregate formation. Formation of inclusion complexes was confirmed by DSC, FT-IR and 1 H-NMR studies. A mixture of 15% (w/v) γ CD and 8% (w/v) HPβCD was selected for formulation studies. It was concluded that formulations with aggregate sizes less than 1 μm and viscosity around 10-19 centipoises can be easily prepared using a mixture of CDs. Formulations containing polymeric drug/CD nanoaggregates represent an interesting strategy for enhanced topical delivery of nepafenac. |
dc.description.sponsorship |
This research received no external funding. |
dc.format.extent |
229 |
dc.language.iso |
en |
dc.publisher |
MDPI AG |
dc.relation.ispartofseries |
Materials;12(2) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Aggregate |
dc.subject |
Complexation |
dc.subject |
Cyclodextrin |
dc.subject |
Nepafenac |
dc.subject |
Ocular drug delivery |
dc.subject |
Polymer |
dc.subject |
Self-assemble |
dc.subject |
Lyfjaefnafræði |
dc.subject |
Lyf |
dc.subject |
Augnsjúkdómar |
dc.subject |
Lyfhrifafræði |
dc.subject |
Sýklódextrín |
dc.title |
Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Materials |
dc.identifier.doi |
10.3390/ma12020229 |
dc.relation.url |
http://www.mdpi.com/1996-1944/12/2/229/pdf |
dc.contributor.department |
Lyfjafræðideild (HÍ) |
dc.contributor.department |
Faculty of Pharmaceutical Sciences (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |