Titill: | Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study |
Höfundur: |
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Útgáfa: | 2019-01-22 |
Tungumál: | Enska |
Umfang: | 1527-1534 |
Háskóli/Stofnun: | Háskóli Íslands University of Iceland |
Svið: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Verkfræði- og náttúruvísindasvið (HÍ) School of Engineering and Natural Sciences (UI) |
Deild: | Læknadeild (HÍ) Faculty of Medicine (UI) Raunvísindadeild (HÍ) Faculty of Physical Sciences (UI) |
Birtist í: | Acta Paediatrica;108(8) |
ISSN: | 0803-5253 |
DOI: | 10.1111/apa.14724 |
Efnisorð: | Conjugate vaccines; Middle ear ventilation; Otitis media; PHiD-CV vaccine; Streptococcus pneumoniae; Bóluefni; Bólusetningar; Pneumókokkar; Börn; Tilviksrannsóknir |
URI: | https://hdl.handle.net/20.500.11815/1671 |
Tilvitnun:Eythorsson, Elias, Sigurdsson, Samuel, Erlendsdóttir, Helga, Hrafnkelsson, Birgir, Kristinsson, Karl G, & Haraldsson, Ásgeir. (2019). Increase in Tympanostomy Tube Placements despite Pneumococcal Vaccination, a Population-based Study., 30667099.
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Útdráttur:Aim: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. Methods: This population-based observational cohort study followed 11 consecutive birth-cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%. Results: In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts. Conclusion: Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative.
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Athugasemdir:Publisher's version (útgefin grein)
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Leyfi:This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium,
provided the original work is properly cited and is not used for commercial purposes.
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