dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Eyþórsson, Elías |
dc.contributor.author |
Sigurdsson, Samuel |
dc.contributor.author |
Erlendsdóttir, Helga |
dc.contributor.author |
Hrafnkelsson, Birgir |
dc.contributor.author |
Kristinsson, Karl G. |
dc.contributor.author |
Haraldsson, Ásgeir |
dc.date.accessioned |
2020-03-30T14:59:10Z |
dc.date.available |
2020-03-30T14:59:10Z |
dc.date.issued |
2019-01-22 |
dc.identifier.citation |
Eythorsson, Elias, Sigurdsson, Samuel, Erlendsdóttir, Helga, Hrafnkelsson, Birgir, Kristinsson, Karl G, & Haraldsson, Ásgeir. (2019). Increase in Tympanostomy Tube Placements despite Pneumococcal Vaccination, a Population-based Study., 30667099. |
dc.identifier.issn |
0803-5253 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1671 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Aim: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. Methods: This population-based observational cohort study followed 11 consecutive birth-cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%. Results: In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts. Conclusion: Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative. |
dc.description.sponsorship |
An investigator-initiated study funded by GlaxoSmithKline Biologicals SA. Additionally, a grant was received from the Landspitali University Hospital Research Fund. GlaxoSmithKline Biologicals SA was provided the opportunity to review a draft version of this manuscript, but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript. |
dc.format.extent |
1527-1534 |
dc.language.iso |
en |
dc.publisher |
Wiley |
dc.relation.ispartofseries |
Acta Paediatrica;108(8) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Conjugate vaccines |
dc.subject |
Middle ear ventilation |
dc.subject |
Otitis media |
dc.subject |
PHiD-CV vaccine |
dc.subject |
Streptococcus pneumoniae |
dc.subject |
Bóluefni |
dc.subject |
Bólusetningar |
dc.subject |
Pneumókokkar |
dc.subject |
Börn |
dc.subject |
Tilviksrannsóknir |
dc.title |
Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium,
provided the original work is properly cited and is not used for commercial purposes. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Acta Paediatrica, International Journal of Paediatrics |
dc.identifier.doi |
10.1111/apa.14724 |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.department |
Raunvísindadeild (HÍ) |
dc.contributor.department |
Faculty of Physical Sciences (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |
dc.contributor.school |
Verkfræði- og náttúruvísindasvið (HÍ) |
dc.contributor.school |
School of Engineering and Natural Sciences (UI) |