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Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Eyþórsson, Elías
dc.contributor.author Sigurdsson, Samuel
dc.contributor.author Erlendsdóttir, Helga
dc.contributor.author Hrafnkelsson, Birgir
dc.contributor.author Kristinsson, Karl G.
dc.contributor.author Haraldsson, Ásgeir
dc.date.accessioned 2020-03-30T14:59:10Z
dc.date.available 2020-03-30T14:59:10Z
dc.date.issued 2019-01-22
dc.identifier.citation Eythorsson, Elias, Sigurdsson, Samuel, Erlendsdóttir, Helga, Hrafnkelsson, Birgir, Kristinsson, Karl G, & Haraldsson, Ásgeir. (2019). Increase in Tympanostomy Tube Placements despite Pneumococcal Vaccination, a Population-based Study., 30667099.
dc.identifier.issn 0803-5253
dc.identifier.uri https://hdl.handle.net/20.500.11815/1671
dc.description Publisher's version (útgefin grein)
dc.description.abstract Aim: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. Methods: This population-based observational cohort study followed 11 consecutive birth-cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%. Results: In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts. Conclusion: Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative.
dc.description.sponsorship An investigator-initiated study funded by GlaxoSmithKline Biologicals SA. Additionally, a grant was received from the Landspitali University Hospital Research Fund. GlaxoSmithKline Biologicals SA was provided the opportunity to review a draft version of this manuscript, but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript.
dc.format.extent 1527-1534
dc.language.iso en
dc.publisher Wiley
dc.relation.ispartofseries Acta Paediatrica;108(8)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Conjugate vaccines
dc.subject Middle ear ventilation
dc.subject Otitis media
dc.subject PHiD-CV vaccine
dc.subject Streptococcus pneumoniae
dc.subject Bóluefni
dc.subject Bólusetningar
dc.subject Pneumókokkar
dc.subject Börn
dc.subject Tilviksrannsóknir
dc.title Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.description.version Peer Reviewed
dc.identifier.journal Acta Paediatrica, International Journal of Paediatrics
dc.identifier.doi 10.1111/apa.14724
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.department Raunvísindadeild (HÍ)
dc.contributor.department Faculty of Physical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)
dc.contributor.school Verkfræði- og náttúruvísindasvið (HÍ)
dc.contributor.school School of Engineering and Natural Sciences (UI)

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