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Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Xu, Jason
dc.contributor.author Bjornsson, Einar
dc.contributor.author Sundaram, Vinay
dc.date.accessioned 2018-11-12T15:56:20Z
dc.date.available 2018-11-12T15:56:20Z
dc.date.issued 2015-12-14
dc.identifier.citation Xu, J., Björnsson, E. S., & Sundaram, V. (2018). Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases. Gastroenterology Report, 6(1), 68-71. doi:10.1093/gastro/gov061
dc.identifier.issn 2052-0034
dc.identifier.uri https://hdl.handle.net/20.500.11815/895
dc.description Publisher's version (útgefin grein)
dc.description.abstract Giant cell arteritis (GCA) is a vasculitis of medium and large sized vessels that occurs most often in people >50 years of age with associated symptoms of fever, weight loss, headache and jaw claudication. Polymyalgia rheumatica (PMR), which is characterized by aching and stiffness in the shoulders, hip girdle, neck and torso, is intimately associated with GCA, and evidence suggests that GCA and PMR are two phases of the same disease. The occurrence of liver enzyme abnormalities in either of these conditions is rare. Furthermore, as these conditions occur most commonly in the elderly population who may be subject to polypharmacy, patients with elevated aminotransferases due to underlying GCA/PMR may mistakenly have their abnormal liver function tests attributed to drug-induced liver injury. Given the potential complications of these diseases if left untreated, including ischemic stroke and blindness, early recognition and treatment are critical. We report two patients who developed severe cholestatic liver enzyme elevation, which had been initially attributed to drug toxicity, but was ultimately caused by large vessel vasculitis, specifically GCA and PMR.
dc.format.extent 68-71
dc.language.iso en
dc.publisher Oxford University Press (OUP)
dc.relation.ispartofseries Gastroenterology Report;6(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Liver injuries
dc.subject Giant cell arteritis
dc.subject Polymyalgia rheumatica
dc.subject Abnormal liver enzymes
dc.subject Lifrarsjúkdómar
dc.subject Gigtarsjúkdómar
dc.title Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases
dc.type info:eu-repo/semantics/article
dcterms.license This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.description.version Peer Reviewed
dc.identifier.journal Gastroenterology Report
dc.identifier.doi 10.1093/gastro/gov061
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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