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Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases

Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases


Titill: Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases
Höfundur: Xu, Jason
Bjornsson, Einar   orcid.org/0000-0002-8392-0632
Sundaram, Vinay
Útgáfa: 2015-12-14
Tungumál: Enska
Umfang: 68-71
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Gastroenterology Report;6(1)
ISSN: 2052-0034
DOI: 10.1093/gastro/gov061
Efnisorð: Liver injuries; Giant cell arteritis; Polymyalgia rheumatica; Abnormal liver enzymes; Lifrarsjúkdómar; Gigtarsjúkdómar
URI: https://hdl.handle.net/20.500.11815/895

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Tilvitnun:

Xu, J., Björnsson, E. S., & Sundaram, V. (2018). Severe cholestatic hepatitis due to large vessel vasculitis: report of two cases. Gastroenterology Report, 6(1), 68-71. doi:10.1093/gastro/gov061

Útdráttur:

Giant cell arteritis (GCA) is a vasculitis of medium and large sized vessels that occurs most often in people >50 years of age with associated symptoms of fever, weight loss, headache and jaw claudication. Polymyalgia rheumatica (PMR), which is characterized by aching and stiffness in the shoulders, hip girdle, neck and torso, is intimately associated with GCA, and evidence suggests that GCA and PMR are two phases of the same disease. The occurrence of liver enzyme abnormalities in either of these conditions is rare. Furthermore, as these conditions occur most commonly in the elderly population who may be subject to polypharmacy, patients with elevated aminotransferases due to underlying GCA/PMR may mistakenly have their abnormal liver function tests attributed to drug-induced liver injury. Given the potential complications of these diseases if left untreated, including ischemic stroke and blindness, early recognition and treatment are critical. We report two patients who developed severe cholestatic liver enzyme elevation, which had been initially attributed to drug toxicity, but was ultimately caused by large vessel vasculitis, specifically GCA and PMR.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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