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Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Bjarnason, Agnar
dc.contributor.author Westin, Johan
dc.contributor.author Lindh, Magnus
dc.contributor.author Andersson, Lars-Magnus
dc.contributor.author Kristinsson, Karl G.
dc.contributor.author Löve, Arthur
dc.contributor.author Baldursson, Ólafur
dc.contributor.author Gottfredsson, Magnus
dc.date.accessioned 2018-07-31T16:09:55Z
dc.date.available 2018-07-31T16:09:55Z
dc.date.issued 2018-02-01
dc.identifier.citation Agnar Bjarnason, Johan Westin, Magnus Lindh, Lars-Magnus Andersson, Karl G Kristinsson, Arthur Löve, Olafur Baldursson, Magnus Gottfredsson; Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study, Open Forum Infectious Diseases, Volume 5, Issue 2, 1 February 2018, ofy010, https://doi.org/10.1093/ofid/ofy010
dc.identifier.issn 2328-8957
dc.identifier.uri https://hdl.handle.net/20.500.11815/750
dc.description.abstract Background The microbial etiology of community-acquired pneumonia (CAP) is often unclear in clinical practice, and previous studies have produced variable results. Population-based studies examining etiology and incidence are lacking. This study examined the incidence and etiology of CAP requiring hospitalization in a population-based cohort as well as risk factors and outcomes for specific etiologies. Methods Consecutive admissions due to CAP in Reykjavik, Iceland were studied. Etiologic testing was performed with cultures, urine-antigen detection, and polymerase chain reaction analysis of airway samples. Outcomes were length of stay, intensive care unit admission, assisted ventilation, and mortality. Results The inclusion rate was 95%. The incidence of CAP requiring hospitalization was 20.6 cases per 10000 adults/year. A potential pathogen was detected in 52% (164 of 310) of admissions and in 74% (43 of 58) with complete sample sets. Streptococcuspneumoniae was the most common pathogen (61 of 310, 20%; incidence: 4.1/10000). Viruses were identified in 15% (47 of 310; incidence: 3.1/10000), Mycoplasmapneumoniae were identified in 12% (36 of 310; incidence: 2.4/10000), and multiple pathogens were identified in 10% (30 of 310; incidence: 2.0/10000). Recent antimicrobial therapy was associated with increased detection of M pneumoniae (P < .001), whereas a lack of recent antimicrobial therapy was associated with increased detection of S pneumoniae (P = .02). Symptoms and outcomes were similar irrespective of microbial etiology. Conclusions Pneumococci, M pneumoniae, and viruses are the most common pathogens associated with CAP requiring hospital admission, and they all have a similar incidence that increases with age. Symptoms do not correlate with specific agents, and outcomes are similar irrespective of pathogens identified.
dc.description.sponsorship This work was funded by the Icelandic Center for Research, Rannís (grant number 100436021), the Landspitali University Hospital Science Fund, and the University of Iceland Research Fund.
dc.format.extent UNSP ofy010
dc.language.iso en
dc.publisher Oxford University Press (OUP)
dc.relation.ispartofseries Open Forum Infectious Diseases;5(2)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Community acquired pneumonia
dc.subject Etiology
dc.subject Incidence
dc.subject Mycoplasma pneumoniae
dc.subject Streptococcus pneumoniae
dc.subject Lungnabólga
dc.subject Algengi sjúkdóma
dc.title Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study
dc.type info:eu-repo/semantics/article
dcterms.license This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
dc.description.version Peer Reviewed
dc.identifier.journal Open Forum Infectious Diseases
dc.identifier.doi 10.1093/ofid/ofy010
dc.relation.url http://academic.oup.com/ofid/article-pdf/5/2/ofy010/23842929/ofy010.pdf
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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