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Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study

Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study


Titill: Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study
Höfundur: Bjarnason, Agnar   orcid.org/0000-0002-2892-3304
Westin, Johan
Lindh, Magnus
Andersson, Lars-Magnus
Kristinsson, Karl G.
Löve, Arthur
Baldursson, Ólafur
Gottfredsson, Magnus   orcid.org/0000-0003-2465-0422
Útgáfa: 2018-02-01
Tungumál: Enska
Umfang: UNSP ofy010
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Open Forum Infectious Diseases;5(2)
ISSN: 2328-8957
DOI: 10.1093/ofid/ofy010
Efnisorð: Community acquired pneumonia; Etiology; Incidence; Mycoplasma pneumoniae; Streptococcus pneumoniae; Lungnabólga; Algengi sjúkdóma
URI: https://hdl.handle.net/20.500.11815/750

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Tilvitnun:

Agnar Bjarnason, Johan Westin, Magnus Lindh, Lars-Magnus Andersson, Karl G Kristinsson, Arthur Löve, Olafur Baldursson, Magnus Gottfredsson; Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study, Open Forum Infectious Diseases, Volume 5, Issue 2, 1 February 2018, ofy010, https://doi.org/10.1093/ofid/ofy010

Útdráttur:

Background The microbial etiology of community-acquired pneumonia (CAP) is often unclear in clinical practice, and previous studies have produced variable results. Population-based studies examining etiology and incidence are lacking. This study examined the incidence and etiology of CAP requiring hospitalization in a population-based cohort as well as risk factors and outcomes for specific etiologies. Methods Consecutive admissions due to CAP in Reykjavik, Iceland were studied. Etiologic testing was performed with cultures, urine-antigen detection, and polymerase chain reaction analysis of airway samples. Outcomes were length of stay, intensive care unit admission, assisted ventilation, and mortality. Results The inclusion rate was 95%. The incidence of CAP requiring hospitalization was 20.6 cases per 10000 adults/year. A potential pathogen was detected in 52% (164 of 310) of admissions and in 74% (43 of 58) with complete sample sets. Streptococcuspneumoniae was the most common pathogen (61 of 310, 20%; incidence: 4.1/10000). Viruses were identified in 15% (47 of 310; incidence: 3.1/10000), Mycoplasmapneumoniae were identified in 12% (36 of 310; incidence: 2.4/10000), and multiple pathogens were identified in 10% (30 of 310; incidence: 2.0/10000). Recent antimicrobial therapy was associated with increased detection of M pneumoniae (P < .001), whereas a lack of recent antimicrobial therapy was associated with increased detection of S pneumoniae (P = .02). Symptoms and outcomes were similar irrespective of microbial etiology. Conclusions Pneumococci, M pneumoniae, and viruses are the most common pathogens associated with CAP requiring hospital admission, and they all have a similar incidence that increases with age. Symptoms do not correlate with specific agents, and outcomes are similar irrespective of pathogens identified.

Leyfi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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