dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Reginsson, Gunnar W. |
dc.contributor.author |
Ingason, Andrés |
dc.contributor.author |
Euesden, Jack |
dc.contributor.author |
Bjornsdottir, Gyda |
dc.contributor.author |
Ólafsson, Sigurgeir |
dc.contributor.author |
Sigurdsson, Engilbert |
dc.contributor.author |
Óskarsson, Högni |
dc.contributor.author |
Tyrfingsson, Þórarinn |
dc.contributor.author |
Rúnarsdóttir, Valgerður |
dc.contributor.author |
Hansdóttir, Ingunn |
dc.contributor.author |
Steinberg, Stacy |
dc.contributor.author |
Stefánsson, Hreinn |
dc.contributor.author |
Gudbjartsson, Daniel |
dc.contributor.author |
Thorgeirsson, Thorgeir |
dc.contributor.author |
Stefansson, Kari |
dc.date.accessioned |
2018-05-02T13:42:06Z |
dc.date.available |
2018-05-02T13:42:06Z |
dc.date.issued |
2017-02-23 |
dc.identifier.citation |
Reginsson, G. W., Ingason, A., Euesden, J., Bjornsdottir, G., Olafsson, S., Sigurdsson, E., . . . Stefansson, K. (2018). Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction. Addiction Biology, 23(1), 485-492. doi:doi:10.1111/adb.12496 |
dc.identifier.issn |
1355-6215 |
dc.identifier.issn |
1369-1600 (eISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/708 |
dc.description.abstract |
We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior. |
dc.description.sponsorship |
This study was funded
in part by the National Institute on Drug Abuse (NIDA)
(R01-DA017932 and R01-DA034076), and it received
support from the European Community’s Seventh Framework
Programme under the Marie Curie Industry Academia
Partnership and Pathways (PsychDPC, GA 286213). |
dc.format.extent |
485-492 |
dc.language.iso |
en |
dc.publisher |
Wiley |
dc.relation |
"info:eu-repo/grantAgreement/EC/FP7/GA 286213" |
dc.relation.ispartofseries |
Addiction Biology;23(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Polygenic scores |
dc.subject |
Psychotic disorders |
dc.subject |
Substance abuse |
dc.subject |
Fíkn |
dc.subject |
Tóbaksnotkun |
dc.subject |
Áfengissýki |
dc.subject |
Fíkniefnaneysla |
dc.subject |
Geðklofi |
dc.subject |
Geðhvarfasýki |
dc.title |
Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and
distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Addiction Biology |
dc.identifier.doi |
10.1111/adb.12496 |
dc.contributor.department |
Sálfræðideild (HÍ) |
dc.contributor.department |
Faculty of Psychology (UI) |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |
dc.contributor.school |
Verkfræði- og náttúruvísindasvið (HÍ) |
dc.contributor.school |
School of Engineering and Natural Sciences (UI) |