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Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction


Titill: Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
Höfundur: Reginsson, Gunnar W.
Ingason, Andres
Euesden, Jack
Bjornsdottir, Gyda   orcid.org/0000-0002-8100-0306
Ólafsson, Sigurgeir   orcid.org/0000-0003-1711-2757
Sigurdsson, Engilbert   orcid.org/0000-0001-9404-7982
Óskarsson, Högni
Tyrfingsson, Þórarinn
Rúnarsdóttir, Valgerður
Hansdóttir, Ingunn   orcid.org/0000-0001-9502-327X
... 5 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-02-23
Tungumál: Enska
Umfang: 485-492
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Verkfræði- og náttúruvísindasvið (HÍ)
School of Engineering and Natural Sciences (UI)
Deild: Sálfræðideild (HÍ)
Faculty of Psychology (UI)
Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Addiction Biology;23(1)
ISSN: 1355-6215
1369-1600 (eISSN)
DOI: 10.1111/adb.12496
Efnisorð: Polygenic scores; Psychotic disorders; Substance abuse; Fíkn; Tóbaksnotkun; Áfengissýki; Fíkniefnaneysla; Geðklofi; Geðhvarfasýki
URI: https://hdl.handle.net/20.500.11815/708

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Tilvitnun:

Reginsson, G. W., Ingason, A., Euesden, J., Bjornsdottir, G., Olafsson, S., Sigurdsson, E., . . . Stefansson, K. (2018). Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction. Addiction Biology, 23(1), 485-492. doi:doi:10.1111/adb.12496

Útdráttur:

We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.

Leyfi:

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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