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Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Farioli, Andrea
dc.contributor.author Straif, Kurt
dc.contributor.author Brandi, Giovanni
dc.contributor.author Curti, Stefania
dc.contributor.author Kjaerheim, Kristina
dc.contributor.author Martinsen, Jan Ivar
dc.contributor.author Sparen, Pär
dc.contributor.author Tryggvadottir, Laufey
dc.contributor.author Weiderpass, Elisabete
dc.contributor.author Biasco, Guido
dc.contributor.author Violante, Francesco Saverio
dc.contributor.author Mattioli, Stefano
dc.contributor.author Pukkala, Eero
dc.date.accessioned 2018-04-24T15:01:29Z
dc.date.available 2018-04-24T15:01:29Z
dc.date.issued 2017-11-13
dc.identifier.citation Farioli, A., Straif, K., Brandi, G., Curti, S., Kjaerheim, K., Martinsen, J. I., . . . Pukkala, E. (2018). Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries. Occupational and Environmental Medicine, 75(3), 191-198. doi:10.1136/oemed-2017-104603
dc.identifier.issn 1351-0711
dc.identifier.issn 1470-7926 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/698
dc.description.abstract Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed.
dc.description.sponsorship Nordic Cancer Union funded the NOCCA project. The work by AF, GBr, SC, GBi, FSV and SM was partially supported by internal funds of the Department of Medical and Surgical Sciences and the Department of Experimental, Diagnostic, and Specialty Medicine of the University of Bologna.
dc.format.extent 191-198
dc.language.iso en
dc.publisher BMJ
dc.relation.ispartofseries Occupational and Environmental Medicine;75(3)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Tilviksrannsóknir
dc.subject Krabbamein
dc.subject Gallrás
dc.subject Asbest
dc.subject Vinnuaðstaða
dc.title Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries
dc.type info:eu-repo/semantics/article
dcterms.license This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
dc.description.version Peer Reviewed
dc.identifier.journal Occupational and Environmental Medicine
dc.identifier.doi 10.1136/oemed-2017-104603
dc.relation.url https://syndication.highwire.org/content/doi/10.1136/oemed-2017-104603
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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