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Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries

Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries


Titill: Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries
Höfundur: Farioli, Andrea
Straif, Kurt
Brandi, Giovanni
Curti, Stefania
Kjaerheim, Kristina
Martinsen, Jan Ivar
Sparen, Pär
Tryggvadottir, Laufey   orcid.org/0000-0001-8067-9030
Weiderpass, Elisabete
Biasco, Guido
... 3 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-11-13
Tungumál: Enska
Umfang: 191-198
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Occupational and Environmental Medicine;75(3)
ISSN: 1351-0711
1470-7926 (eISSN)
DOI: 10.1136/oemed-2017-104603
Efnisorð: Tilviksrannsóknir; Krabbamein; Gallrás; Asbest; Vinnuaðstaða
URI: https://hdl.handle.net/20.500.11815/698

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Tilvitnun:

Farioli, A., Straif, K., Brandi, G., Curti, S., Kjaerheim, K., Martinsen, J. I., . . . Pukkala, E. (2018). Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries. Occupational and Environmental Medicine, 75(3), 191-198. doi:10.1136/oemed-2017-104603

Útdráttur:

Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed.

Leyfi:

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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