Greinar- HÍ: Recent submissions

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    NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease 
    Bindesbøll, Christian; Aas, Aleksander; Ogmundsdottir, Margret H; Pankiv, Serhiy; Reine, Trine; Zoncu, Roberto; Simonsen, Anne (Springer Science and Business Media LLC, 2020-03-11)
    Dysregulated cholesterol homeostasis promotes the pathology of atherosclerosis, myocardial infarction and strokes. Cellular cholesterol is mainly regulated at the transcriptional level by SREBP2, but also through uptake of extracellular cholesterol ...
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    Taxogenomic assessment and genomic characterisation of Weissella cibaria strain 92 able to metabolise oligosaccharides derived from dietary fibres 
    Månberger, Anna; Verbrugghe, Phebe; Guðmundsdóttir, Elísabet Eik; Santesson, Sara; Nilsson, Anne; Hreggvidsson, Gudmundur Oli; Linares-Pastén, Javier A.; Nordberg Karlsson, Eva (Springer Science and Business Media LLC, 2020-04-03)
    The importance of the gut microbiota in human health has led to an increased interest to study probiotic bacteria. Fermented food is a source of already established probiotics, but it also offers an opportunity to discover new taxa. Four strains of ...
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    Nonlinear polaritons in a monolayer semiconductor coupled to optical bound states in the continuum 
    Kravtsov, Vasily; Khestanova, Ekaterina; Benimetskiy, Fedor A.; Ivanova, Tatiana; Samusev, Anton K.; Sinev, Ivan S.; Pidgayko, Dmitry; Mozharov, Alexey M.; Mukhin, Ivan S.; Lozhkin, Maksim S.; Kapitonov, Yuri V.; Brichkin, Andrey S.; Kulakovskii, Vladimir D.; Shelykh, Ivan; Tartakovskii, Alexander I.; Walker, Paul M.; Skolnick, Maurice S.; Krizhanovskii, Dmitry N.; Iorsh, Ivan V. (Springer Science and Business Media LLC, 2020-04-09)
    Optical bound states in the continuum (BICs) provide a way to engineer very narrow resonances in photonic crystals. The extended interaction time in these systems is particularly promising for the enhancement of nonlinear optical processes and the ...
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    Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis 
    Óskarsson, Guðjón R.; Oddsson, Asmundur; Magnusson, Magnus Karl; Kristjansson, Ragnar; Halldorsson, Gisli; Ferkingstad, Egil; Zink, Florian; Helgadottir, Anna; Ívarsdóttir, Erna V.; Arnadottir, Gudny; Jensson, Brynjar Örn; Katrinardottir, Hildigunnur; Sveinbjornsson, Gardar; Kristinsdóttir, Anna Margrét; Lee, Amy L.; Sæmundsdóttir, Jóna; Stefánsdóttir, Lilja; Sigurðsson, Jón K.; Davíðsson, Ólafur B.; Benonisdottir, Stefania; Jónasdóttir, Áslaug; Jónasdóttir, Aðalbjörg; Jonsson, Stefan; Guðmundsson, Reynir L.; Asselbergs, Folkert W.; Tragante, Vinicius; Gunnarsson, Bjarni; Másson, Gísli; Thorleifsson, Gudmar; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Önundarson, Páll Torfi; Gudbjartsson, Daniel; Norðdahl, Guðmundur L.; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2020-04-23)
    Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and oxygen sensing mechanisms. To search for novel variants associated with hemoglobin concentration, we performed genome-wide association studies of ...
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    Unexpected large eruptions from buoyant magma bodies within viscoelastic crust 
    Sigmundsson, Freysteinn; Pinel, Virginie; Grapenthin, Ronni; Hooper, Andrew; Halldórsson, Sæmundur Ari; Einarsson, Páll; Ófeigsson, Benedikt G.; Heimisson, Elias; Jónsdóttir, Kristín; Gudmundsson, Magnus Tumi; Vogfjörð, Kristín; Parks, Michelle; Li, Siqi; Drouin, Vincent; Geirsson, Halldor; Dumont, Stéphanie; Friðriksdóttir, Hildur M.; Guðmundsson, Gunnar B.; Wright, Tim J.; Yamasaki, Tadashi (Springer Science and Business Media LLC, 2020-05-15)
    Large volume effusive eruptions with relatively minor observed precursory signals are at odds with widely used models to interpret volcano deformation. Here we propose a new modelling framework that resolves this discrepancy by accounting for magma ...
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    Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction 
    Ntalla, Ioanna; Weng, Lu-Chen; Cartwright, James H.; Hall, Amelia Weber; Sveinbjornsson, Gardar; Tucker, Nathan R.; Choi, Seung Hoan; Chaffin, Mark D.; Roselli, Carolina; Barnes, Michael R.; Mifsud, Borbala; Warren, Helen R.; Hayward, Caroline; Marten, Jonathan; Cranley, James J.; Concas, Maria Pina; Gasparini, Paolo; Boutin, Thibaud; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Araujo, Nathalia M.; Lima-Costa, Maria Fernanda; Ribeiro, Antonio Luiz P.; Souza, Renan P.; Tarazona-Santos, Eduardo; Giedraitis, Vilmantas; Ingelsson, Erik; Mahajan, Anubha; Morris, Andrew P.; Del Greco M, Fabiola; Foco, Luisa; Gögele, Martin; Hicks, Andrew A.; Cook, James P.; Lind, Lars; Lindgren, Cecilia M.; Sundström, Johan; Nelson, Christopher P.; Riaz, Muhammad B.; Samani, Nilesh J.; Sinagra, Gianfranco; Ulivi, Sheila; Kähönen, Mika; Mishra, Pashupati P.; Mononen, Nina; Nikus, Kjell; Caulfield, Mark J.; Dominiczak, Anna; Padmanabhan, Sandosh; Montasser, May E.; O’Connell, Jeff R.; Ryan, Kathleen; Shuldiner, Alan R.; Aeschbacher, Stefanie; Conen, David; Risch, Lorenz; Thériault, Sébastien; Hutri-Kähönen, Nina; Lehtimäki, Terho; Lyytikäinen, Leo-Pekka; Raitakari, Olli T.; Barnes, Catriona L. K.; Campbell, Harry; Joshi, Peter K.; Wilson, James F.; Isaacs, Aaron; Kors, Jan A.; van Duijn, Cornelia M.; Huang, Paul L.; Gudnason, Vilmundur; Harris, Tamara B.; Launer, Lenore J.; Smith, Albert Vernon; Bottinger, Erwin P.; Loos, Ruth J. F.; Nadkarni, Girish N.; Preuss, Michael H.; Correa, Adolfo; Mei, Hao; Wilson, James; Meitinger, Thomas; Müller-Nurasyid, Martina; Peters, Annette; Waldenberger, Melanie; Mangino, Massimo; Spector, Timothy D.; Rienstra, Michiel; van de Vegte, Yordi J.; van der Harst, Pim; Verweij, Niek; Kääb, Stefan; Schramm, Katharina; Sinner, Moritz F.; Strauch, Konstantin; Cutler, Michael J.; Fatkin, Diane; London, Barry; Olesen, Morten; Roden, Dan M.; Benjamin Shoemaker, M.; Gustav Smith, J.; Biggs, Mary L.; Bis, Joshua C.; Brody, Jennifer A.; Psaty, Bruce M.; Rice, Kenneth; Sotoodehnia, Nona; De Grandi, Alessandro; Fuchsberger, Christian; Pattaro, Cristian; Pramstaller, Peter P.; Ford, Ian; Wouter Jukema, J.; Macfarlane, Peter W.; Trompet, Stella; Dörr, Marcus; Felix, Stephan B.; Völker, Uwe; Weiss, Stefan; Havulinna, Aki S.; Jula, Antti; Sääksjärvi, Katri; Salomaa, Veikko; Guo, Xiuqing; Heckbert, Susan R.; Lin, Henry J.; Rotter, Jerome I.; Taylor, Kent D.; Yao, Jie; de Mutsert, Renée; Maan, Arie C.; Mook-Kanamori, Dennis O.; Noordam, Raymond; Cucca, Francesco; Ding, Jun; Lakatta, Edward G.; Qian, Yong; Tarasov, Kirill V.; Levy, Daniel; Lin, Honghuang; Newton-Cheh, Christopher H.; Lunetta, Kathryn L.; Murray, Alison D.; Porteous, David J.; Smith, Blair H.; Stricker, Bruno H.; Uitterlinden, André; van den Berg, Marten E.; Haessler, Jeffrey; Jackson, Rebecca D.; Kooperberg, Charles; Peters, Ulrike; Reiner, Alexander P.; Whitsel, Eric A.; Alonso, Alvaro; Arking, Dan E.; Boerwinkle, Eric; Ehret, Georg B.; Soliman, Elsayed Z.; Avery, Christy L.; Gogarten, Stephanie M.; Kerr, Kathleen F.; Laurie, Cathy C.; Seyerle, Amanda A.; Stilp, Adrienne; Assa, Solmaz; Abdullah Said, M.; Yldau van der Ende, M.; Lambiase, Pier D.; Orini, Michele; Ramirez, Julia; Van Duijvenboden, Stefan; Arnar, Davíð O.; Gudbjartsson, Daniel; Holm, Hilma; sulem, patrick; Thorleifsson, Gudmar; Thorolfsdottir, Rosa B; Thorsteinsdottir, Unnur; Benjamin, Emelia J.; Tinker, Andrew; Stefansson, Kari; Ellinor, Patrick T.; Jamshidi, Yalda; Lubitz, Steven A.; Munroe, Patricia B. (Springer Science and Business Media LLC, 2020-05-21)
    The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) ...
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    Logarithmic negativity in quantum Lifshitz theories 
    Angel Ramelli, Juan Fernando; Berthiere, C.; Giangreco Puletti, Valentina; Thorlacius, Larus (Springer Science and Business Media LLC, 2020-09)
    We investigate quantum entanglement in a non-relativistic critical system by calculating the logarithmic negativity of a class of mixed states in the quantum Lifshitz model in one and two spatial dimensions. In 1+1 dimensions we employ a correlator ...
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    In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation 
    Lorenzo Veiga, Blanca; Diaz-Rodriguez, Patricia; Alvarez-Lorenzo, Carmen; Loftsson, Thorsteinn; Sigurdsson, Hakon Hrafn (MDPI AG, 2020-04-09)
    The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in the posterior segment, thus ...
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    A proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells 
    Thuault, Sylvie; Mamelonet, Claire; Salameh, Joëlle; Ostacolo, Kevin; Chanez, Brice; Salaün, Danièle; Baudelet, Emilie; Audebert, Stéphane; Camoin, Luc; Badache, Ali (Springer Science and Business Media LLC, 2020-04-22)
    Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and the interstitial matrix. Substantial efforts have been made to characterize invadopodia molecular ...
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    A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank 
    Shen, Xueyi; Sigurdsson, Engilbert; Stefansson, Kari (Springer Science and Business Media LLC, 2020-05-08)
    Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate ...
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    A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine 
    Guo, Yanjun; Stefansson, Kari (Springer Science and Business Media LLC, 2020-07-06)
    Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP ...
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    Highly nonlinear trion-polaritons in a monolayer semiconductor 
    Emmanuele, R. P. A.; Sich, M.; Kyriienko, O.; Shahnazaryan, V.; Withers, F.; Catanzaro, A.; Walker, P. M.; Benimetskiy, F. A.; Skolnick, M. S.; Tartakovskii, A. I.; Shelykh, Ivan; Krizhanovskiǐ, Dmitry N. (Springer Science and Business Media LLC, 2020-07-17)
    Highly nonlinear optical materials with strong effective photon-photon interactions are required for ultrafast and quantum optical signal processing circuitry. Here we report strong Kerr-like nonlinearities by employing efficient optical transitions ...
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    Seismic ground vibrations give advanced early-warning of subglacial floods 
    Eibl, Eva; Bean, Christopher J.; Einarsson, Bergur; Pálsson, Finnur; Vogfjörd, Kristín S. (Springer Science and Business Media LLC, 2020-07-21)
    Glacier runoff and melt from volcanic and geothermal activity accumulates in glacier dammed lakes in glaciated areas around the world. These lakes eventually drain, creating hazardous subglacial floods that are usually only confirmed after they exit ...
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    A comparative study of life cycle carbon emissions and embodied energy between sun-dried bricks and fired clay bricks 
    Dabaieh, Marwa; Heinonen, Jukka; El-Mahdy, Deena; Hassan, Dalya M. (Elsevier BV, 2020-12-01)
    This study presents a comparison of the life cycle carbon emission (LCCO2) and embodied energy calculation between two kinds of bricks, sun-dried and fired clay, as means of evaluating the energy and climate impact of each brick type and the economics ...
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    Engineering the carotenoid biosynthetic pathway in Rhodothermus marinus for lycopene production 
    Kristjánsdóttir, Þórdís; Ron, Emanuel Y.C.; Molins-Delgado, Daniel; Fridjonsson, Olafur; Turner, Charlotta; Björnsdóttir, Snædís; Guðmundsson, Steinn; van Niel, Ed W.J.; Karlsson, Eva Nordberg; Hreggvidsson, Gudmundur Oli (Elsevier BV, 2020-12)
    Rhodothermus marinus has the potential to be well suited for biorefineries, as an aerobic thermophile that produces thermostable enzymes and is able to utilize polysaccharides from different 2nd and 3rd generation biomass. The bacterium produces valuable ...
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    GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 
    Zhou, Wei; Brumpton, Ben; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Josh; Zawistowski, Matthew; Nielsen, Jonas B.; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne; Karjalainen, Juha; Kurki, Mitja; Oneka, Morgan; Taylor, Peter; Fritsche, Lars G.; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Haug, Eirin B.; Gabrielsen, Maiken E.; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney E.; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Springer Science and Business Media LLC, 2020-08-07)
    Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify ...
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    Implications of Climate Change on Nature-Based Tourism Demand: A Segmentation Analysis of Glacier Site Visitors in Southeast Iceland 
    Welling, Johannes; Árnason, Þorvarður; Olafsdottir, Rannveig (MDPI AG, 2020-07-01)
    Since the end of the 20th century, glaciers are shrinking at an accelerated pace worldwide. This fuels the concern that increased glacier recession will lead to changes in the accessibility, safety, and amenity of many popular glacier tourist ...
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    T-patterns, external memory and mass-societies in proteins and humans: In an eye-blink the naked ape became a string-controlled citizen 
    Magnússon, Magnús S. (Elsevier BV, 2020-12-01)
    This project started in the 1970′s inspired by biological behavior research (Morris, 1967; Tinbergen, 1965) including that of N. Tinbergen, K. Lorenz and K. von Frisch, for which they shared a Nobel Prize in 1973 in Medicine or Physiology, the first ...
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    A shared genetic contribution to breast cancer and schizophrenia 
    Lu, Donghao; Song, Jie; Lu, Yi; Fall, Katja; Chen, Xu; Fang, Fang; Landén, Mikael; Hultman, Christina M.; Czene, Kamila; Sullivan, Patrick; Tamimi, Rulla M.; Valdimarsdottir, Unnur (Springer Science and Business Media LLC, 2020-09-15)
    An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic ...
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    Downscaling consumption to universal basic income level falls short of sustainable carbon footprint in Finland 
    Kalaniemi, Salla; Ottelin, Juudit; Heinonen, Jukka; Junnila, Seppo (Elsevier BV, 2020-12)
    Human economic activities and following carbon emissions have been recognized to be a real threat to the environment. The current levels of consumption-based carbon footprints in all developed economies grossly exceed the sustainable level. Scientists ...