Browsing Greinar- HÍ by Subject "Drug Discovery"

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Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureus

Kulkarni, Amogh; Soni, Isha; Kelkar, Dhanashree S.; Dharmaraja, Allimuthu T.; Sankar, Rathinam K.; Beniwal, Gaurav; Rajendran, Abinaya; Tamhankar, Sharvari; Chopra, Sidharth; Kamat, Siddhesh S.; Chakrapani, Harinath (American Chemical Society (ACS), 2019-06-26)

The alarming global rise in fatalities from multidrug-resistant Staphylococcus aureus (S. aureus) infections has underscored a need to develop new therapies to address this epidemic. Chemoproteomics is valuable in identifying targets for new drugs in ...
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits

Drobnjak, Tijana; Meiri, Hamutal; Mandalá, Maurizio; Huppertz, Berthold; Gizurarson, Sveinbjorn (Dove Medical Press Ltd., 2018-07)

Introduction: Human placental protein 13 (PP13) is a galectin predominantly expressed by the placenta. Low serum concentrations of PP13 in early pregnancy indicate a higher risk of developing preeclampsia. Methods: The pharmacokinetic disposition ...

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