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Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits

Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits


Titill: Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits
Höfundur: Drobnjak, Tijana
Meiri, Hamutal
Mandalá, Maurizio
Huppertz, Berthold
Gizurarson, Sveinbjörn
Útgáfa: 2018-07
Tungumál: Enska
Umfang: 1977-1983
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Lyfjafræðideild (HÍ)
Faculty of Pharmaceutical Sciences (UI)
Birtist í: Drug Design, Development and Therapy;12
ISSN: 1177-8881
DOI: 10.2147/DDDT.S167926
Efnisorð: Pharmacology; Drug Discovery; Pharmaceutical Science; Lyfjafræði; Lyfjaefnafræði; Lyfhrifafræði
URI: https://hdl.handle.net/20.500.11815/856

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Útdráttur:

Introduction: Human placental protein 13 (PP13) is a galectin predominantly expressed by the placenta. Low serum concentrations of PP13 in early pregnancy indicate a higher risk of developing preeclampsia. Methods: The pharmacokinetic disposition and bioavailability of PP13 were determined by single intravenous and subcutaneous administration to 12 healthy New Zealand White rabbits. The serum pharmacokinetic values were determined by enzyme-linked immunosorbent assay, and are best described by a two-compartment model. Results: Both volume of distribution and the area under the curve were dose dependent for the intravenous group (p < 0.01). PP13 elimination half-life was also found to be different between the groups (p < 0.01). The bioavailability of PP13 following subcutaneous administration was found to be 57%. Conclusion: This study shows that the concentration of total PP13 released into the maternal circulation during pregnancy might be much higher than previously estimated.

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