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Browsing Greinar- HÍ by Department "Rannsóknarsetur í kerfislíffræði (HÍ)"

Browsing Greinar- HÍ by Department "Rannsóknarsetur í kerfislíffræði (HÍ)"

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  • Ron, Emanuel Y. C.; Plaza, Merichel; Kristjánsdóttir, Þórdís; Sardari, Roya R. R.; Björnsdóttir, Snædís Huld; Guðmundsson, Steinn; Hreggvidsson, Gudmundur Oli; Turner, Charlotta; van Niel, Ed W. J.; Nordberg-Karlsson, Eva (Wiley-Blackwell, 2017-10-17)
    Rhodothermus marinus, a marine aerobic thermophile, was first isolated from an intertidal hot spring in Iceland. In recent years, the R. marinus strain PRI 493 has been genetically modified, which opens up possibilities for targeted metabolic engineering ...
  • Yi, Zhiqian; Su, Yixi; Xu, Maonian; Bergmann, Andreas; Ingþórsson, Sævar; Rolfsson, Óttar; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur; Fu, Weiqi (MDPI AG, 2018-08-04)
    Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain performance for high product yields towards commercialization. In this study, we generated a ...
  • Hilmarsdóttir, Bylgja; Briem, Eiríkur; Halldórsson, Skarphéðinn; Kricker, Jennifer; Ingthorsson, Saevar; Gústafsdóttir, Sigrún; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2017-05-11)
    Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
  • Einarsdóttir, Eydís; Magnúsdóttir, Manuela; Astarita, Giuseppe; Köck, Matthias; Ögmundsdóttir, Helga M.; Þorsteinsdóttir, Margrét; Rapp, Hans; Omarsdottir, Sesselja; Paglia, Giuseppe (MDPI AG, 2017-02-22)
    Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based ...
  • Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdottir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
  • McGarrity, Sarah; Anuforo, Ósk; Halldórsson, Haraldur; Bergmann, Andreas; Halldórsson, Skarphéðinn; Palsson, Sirus; Henriksen, Hanne H.; Johansson, Pär Ingemar; Rolfsson, Óttar (Springer Nature, 2018-05-01)
    Endothelial dysfunction contributes to sepsis outcome. Metabolic phenotypes associated with endothelial dysfunction are not well characterised in part due to difficulties in assessing endothelial metabolism in situ. Here, we describe the construction ...
  • Vavitsas, Konstantinos; Rue, Emil Østergaard; Stefánsdóttir, Lára Kristín; Gnanasekaran, Thiyagarajan; Blennow, Andreas; Crocoll, Christoph; Guðmundsson, Steinn; Jensen, Poul Erik (Springer Nature, 2017-08-15)
    Background There are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, ...
  • Johansson, Pär Ingemar; Stensballe, Jakob; Ostrowski, SisseRye (Springer Nature, 2017-02-09)
    One quarter of patients suffering from acute critical illness such as severe trauma, sepsis, myocardial infarction (MI) or post cardiac arrest syndrome (PCAS) develop severe hemostatic aberrations and coagulopathy, which are associated with excess ...
  • Fu, Weiqi; Guðmundsson, Steinn; Wichuk, Kristine; Palsson, Sirus; Pálsson, Bernhard Ö; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur (Elsevier BV, 2019-03)
    To convert waste CO2 from flue gases of power plants into value-added products, bio-mitigation technologies show promise. In this study, we cultivated a fast-growing species of green microalgae, Chlorella vulgaris, in different sizes of photobioreactors ...
  • Fahrendorff, Mathilde; Oliveri, Roberto S.; Johansson, Pär Ingemar (Springer Nature, 2017-04-13)
    Background Management of the critically bleeding patient can be encountered in many medical and surgical settings. Common for these patients is a high risk of dying from exsanguination secondary to developing coagulopathy. The purpose of this meta-analysis ...