Háskóli Íslands: Recent submissions

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    Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis 
    Óskarsson, Guðjón R.; Oddsson, Asmundur; Magnusson, Magnus Karl; Kristjansson, Ragnar; Halldorsson, Gisli; Ferkingstad, Egil; Zink, Florian; Helgadottir, Anna; Ívarsdóttir, Erna V.; Arnadottir, Gudny; Jensson, Brynjar Örn; Katrinardottir, Hildigunnur; Sveinbjornsson, Gardar; Kristinsdóttir, Anna Margrét; Lee, Amy L.; Sæmundsdóttir, Jóna; Stefánsdóttir, Lilja; Sigurðsson, Jón K.; Davíðsson, Ólafur B.; Benonisdottir, Stefania; Jónasdóttir, Áslaug; Jónasdóttir, Aðalbjörg; Jonsson, Stefan; Guðmundsson, Reynir L.; Asselbergs, Folkert W.; Tragante, Vinicius; Gunnarsson, Bjarni; Másson, Gísli; Thorleifsson, Gudmar; Rafnar, Thorunn; Holm, Hilma; Olafsson, Isleifur; Önundarson, Páll Torfi; Gudbjartsson, Daniel; Norðdahl, Guðmundur L.; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2020-04-23)
    Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and oxygen sensing mechanisms. To search for novel variants associated with hemoglobin concentration, we performed genome-wide association studies of ...
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    Unexpected large eruptions from buoyant magma bodies within viscoelastic crust 
    Sigmundsson, Freysteinn; Pinel, Virginie; Grapenthin, Ronni; Hooper, Andrew; Halldórsson, Sæmundur Ari; Einarsson, Páll; Ófeigsson, Benedikt G.; Heimisson, Elias; Jónsdóttir, Kristín; Gudmundsson, Magnus Tumi; Vogfjörð, Kristín; Parks, Michelle; Li, Siqi; Drouin, Vincent; Geirsson, Halldor; Dumont, Stéphanie; Friðriksdóttir, Hildur M.; Guðmundsson, Gunnar B.; Wright, Tim J.; Yamasaki, Tadashi (Springer Science and Business Media LLC, 2020-05-15)
    Large volume effusive eruptions with relatively minor observed precursory signals are at odds with widely used models to interpret volcano deformation. Here we propose a new modelling framework that resolves this discrepancy by accounting for magma ...
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    Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction 
    Ntalla, Ioanna; Weng, Lu-Chen; Cartwright, James H.; Hall, Amelia Weber; Sveinbjornsson, Gardar; Tucker, Nathan R.; Choi, Seung Hoan; Chaffin, Mark D.; Roselli, Carolina; Barnes, Michael R.; Mifsud, Borbala; Warren, Helen R.; Hayward, Caroline; Marten, Jonathan; Cranley, James J.; Concas, Maria Pina; Gasparini, Paolo; Boutin, Thibaud; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Araujo, Nathalia M.; Lima-Costa, Maria Fernanda; Ribeiro, Antonio Luiz P.; Souza, Renan P.; Tarazona-Santos, Eduardo; Giedraitis, Vilmantas; Ingelsson, Erik; Mahajan, Anubha; Morris, Andrew P.; Del Greco M, Fabiola; Foco, Luisa; Gögele, Martin; Hicks, Andrew A.; Cook, James P.; Lind, Lars; Lindgren, Cecilia M.; Sundström, Johan; Nelson, Christopher P.; Riaz, Muhammad B.; Samani, Nilesh J.; Sinagra, Gianfranco; Ulivi, Sheila; Kähönen, Mika; Mishra, Pashupati P.; Mononen, Nina; Nikus, Kjell; Caulfield, Mark J.; Dominiczak, Anna; Padmanabhan, Sandosh; Montasser, May E.; O’Connell, Jeff R.; Ryan, Kathleen; Shuldiner, Alan R.; Aeschbacher, Stefanie; Conen, David; Risch, Lorenz; Thériault, Sébastien; Hutri-Kähönen, Nina; Lehtimäki, Terho; Lyytikäinen, Leo-Pekka; Raitakari, Olli T.; Barnes, Catriona L. K.; Campbell, Harry; Joshi, Peter K.; Wilson, James F.; Isaacs, Aaron; Kors, Jan A.; van Duijn, Cornelia M.; Huang, Paul L.; Gudnason, Vilmundur; Harris, Tamara B.; Launer, Lenore J.; Smith, Albert Vernon; Bottinger, Erwin P.; Loos, Ruth J. F.; Nadkarni, Girish N.; Preuss, Michael H.; Correa, Adolfo; Mei, Hao; Wilson, James; Meitinger, Thomas; Müller-Nurasyid, Martina; Peters, Annette; Waldenberger, Melanie; Mangino, Massimo; Spector, Timothy D.; Rienstra, Michiel; van de Vegte, Yordi J.; van der Harst, Pim; Verweij, Niek; Kääb, Stefan; Schramm, Katharina; Sinner, Moritz F.; Strauch, Konstantin; Cutler, Michael J.; Fatkin, Diane; London, Barry; Olesen, Morten; Roden, Dan M.; Benjamin Shoemaker, M.; Gustav Smith, J.; Biggs, Mary L.; Bis, Joshua C.; Brody, Jennifer A.; Psaty, Bruce M.; Rice, Kenneth; Sotoodehnia, Nona; De Grandi, Alessandro; Fuchsberger, Christian; Pattaro, Cristian; Pramstaller, Peter P.; Ford, Ian; Wouter Jukema, J.; Macfarlane, Peter W.; Trompet, Stella; Dörr, Marcus; Felix, Stephan B.; Völker, Uwe; Weiss, Stefan; Havulinna, Aki S.; Jula, Antti; Sääksjärvi, Katri; Salomaa, Veikko; Guo, Xiuqing; Heckbert, Susan R.; Lin, Henry J.; Rotter, Jerome I.; Taylor, Kent D.; Yao, Jie; de Mutsert, Renée; Maan, Arie C.; Mook-Kanamori, Dennis O.; Noordam, Raymond; Cucca, Francesco; Ding, Jun; Lakatta, Edward G.; Qian, Yong; Tarasov, Kirill V.; Levy, Daniel; Lin, Honghuang; Newton-Cheh, Christopher H.; Lunetta, Kathryn L.; Murray, Alison D.; Porteous, David J.; Smith, Blair H.; Stricker, Bruno H.; Uitterlinden, André; van den Berg, Marten E.; Haessler, Jeffrey; Jackson, Rebecca D.; Kooperberg, Charles; Peters, Ulrike; Reiner, Alexander P.; Whitsel, Eric A.; Alonso, Alvaro; Arking, Dan E.; Boerwinkle, Eric; Ehret, Georg B.; Soliman, Elsayed Z.; Avery, Christy L.; Gogarten, Stephanie M.; Kerr, Kathleen F.; Laurie, Cathy C.; Seyerle, Amanda A.; Stilp, Adrienne; Assa, Solmaz; Abdullah Said, M.; Yldau van der Ende, M.; Lambiase, Pier D.; Orini, Michele; Ramirez, Julia; Van Duijvenboden, Stefan; Arnar, Davíð O.; Gudbjartsson, Daniel; Holm, Hilma; sulem, patrick; Thorleifsson, Gudmar; Thorolfsdottir, Rosa B; Thorsteinsdottir, Unnur; Benjamin, Emelia J.; Tinker, Andrew; Stefansson, Kari; Ellinor, Patrick T.; Jamshidi, Yalda; Lubitz, Steven A.; Munroe, Patricia B. (Springer Science and Business Media LLC, 2020-05-21)
    The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) ...
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    Logarithmic negativity in quantum Lifshitz theories 
    Angel Ramelli, Juan Fernando; Berthiere, C.; Giangreco Puletti, Valentina; Thorlacius, Larus (Springer Science and Business Media LLC, 2020-09)
    We investigate quantum entanglement in a non-relativistic critical system by calculating the logarithmic negativity of a class of mixed states in the quantum Lifshitz model in one and two spatial dimensions. In 1+1 dimensions we employ a correlator ...
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    In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation 
    Lorenzo Veiga, Blanca; Diaz-Rodriguez, Patricia; Alvarez-Lorenzo, Carmen; Loftsson, Thorsteinn; Sigurdsson, Hakon Hrafn (MDPI AG, 2020-04-09)
    The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in the posterior segment, thus ...
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    Entanglement in Quantum Lifshitz Theories 
    Angel Ramelli, Juan Fernando (University of Iceland, School of Engineering and Natural Sciences, Faculty of Physical Sciences, 2020-11)
    In recent years, the study of entanglement properties of quantum field theories has led to deep insights in fields as diverse as quantum gravity and condensed matter physics. Originating as effective field theories for certain quantum dimer models, the ...
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    Cyclodextrin nanostructures and ocular drug delivery 
    Lorenzo Veiga, Blanca (University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-10-26)
    Ocular drug delivery is very challenging due to the anatomical and physiological barriers of the eye. Poor aqueous solubility of many drugs and short retention time at ocular surfaces makes the formulation of topical dosage forms even more challenging. ...
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    A proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells 
    Thuault, Sylvie; Mamelonet, Claire; Salameh, Joëlle; Ostacolo, Kevin; Chanez, Brice; Salaün, Danièle; Baudelet, Emilie; Audebert, Stéphane; Camoin, Luc; Badache, Ali (Springer Science and Business Media LLC, 2020-04-22)
    Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and the interstitial matrix. Substantial efforts have been made to characterize invadopodia molecular ...
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    A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank 
    Shen, Xueyi; Sigurdsson, Engilbert; Stefansson, Kari (Springer Science and Business Media LLC, 2020-05-08)
    Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate ...
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    Learning Icelandic in Virtual Reykjavik: Simulating real-life conversations with embodied conversational agents using multimodal clarification requests 
    Bédi, Branislav (Háskóli Íslands, Hugvísindasvið, Mála- og menningardeild, 2020-10-26)
    Þessi doktorsritgerð er hluti af verkefninu Icelandic Language and Culture Training in Virtual Reykjavik, þrívíddartölvuleik sem gerir þeim sem eru að læra íslensku sem annað mál kleift að æfa tal og hlustun. Markmið verkefnisins var að búa til ...
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    Songs for the End of the World: The Poetry of Guðmundur Erlendsson of Fell in Sléttuhlíð 
    Parsons, Katelin Marit (University of Iceland, School of Humanities, Faculty of Icelandic and Comparative Cultural Studies, 2020-11)
    Guðmundur Erlendsson of Fell in Sléttuhlíð (c. 1595–1670) was one of the leading poets of seventeenth-century Iceland. No man is an island, however, nor are islands populated exclusively by men. The thesis examines how Guðmundur Erlendsson’s poetry and ...
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    A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine 
    Guo, Yanjun; Stefansson, Kari (Springer Science and Business Media LLC, 2020-07-06)
    Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP ...
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    Highly nonlinear trion-polaritons in a monolayer semiconductor 
    Emmanuele, R. P. A.; Sich, M.; Kyriienko, O.; Shahnazaryan, V.; Withers, F.; Catanzaro, A.; Walker, P. M.; Benimetskiy, F. A.; Skolnick, M. S.; Tartakovskii, A. I.; Shelykh, Ivan; Krizhanovskiǐ, Dmitry N. (Springer Science and Business Media LLC, 2020-07-17)
    Highly nonlinear optical materials with strong effective photon-photon interactions are required for ultrafast and quantum optical signal processing circuitry. Here we report strong Kerr-like nonlinearities by employing efficient optical transitions ...
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    Seismic ground vibrations give advanced early-warning of subglacial floods 
    Eibl, Eva; Bean, Christopher J.; Einarsson, Bergur; Pálsson, Finnur; Vogfjörd, Kristín S. (Springer Science and Business Media LLC, 2020-07-21)
    Glacier runoff and melt from volcanic and geothermal activity accumulates in glacier dammed lakes in glaciated areas around the world. These lakes eventually drain, creating hazardous subglacial floods that are usually only confirmed after they exit ...
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    A comparative study of life cycle carbon emissions and embodied energy between sun-dried bricks and fired clay bricks 
    Dabaieh, Marwa; Heinonen, Jukka; El-Mahdy, Deena; Hassan, Dalya M. (Elsevier BV, 2020-12-01)
    This study presents a comparison of the life cycle carbon emission (LCCO2) and embodied energy calculation between two kinds of bricks, sun-dried and fired clay, as means of evaluating the energy and climate impact of each brick type and the economics ...
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    Engineering the carotenoid biosynthetic pathway in Rhodothermus marinus for lycopene production 
    Kristjánsdóttir, Þórdís; Ron, Emanuel Y.C.; Molins-Delgado, Daniel; Fridjonsson, Olafur; Turner, Charlotta; Björnsdóttir, Snædís; Guðmundsson, Steinn; van Niel, Ed W.J.; Karlsson, Eva Nordberg; Hreggvidsson, Gudmundur Oli (Elsevier BV, 2020-12)
    Rhodothermus marinus has the potential to be well suited for biorefineries, as an aerobic thermophile that produces thermostable enzymes and is able to utilize polysaccharides from different 2nd and 3rd generation biomass. The bacterium produces valuable ...
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    GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 
    Zhou, Wei; Brumpton, Ben; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Josh; Zawistowski, Matthew; Nielsen, Jonas B.; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne; Karjalainen, Juha; Kurki, Mitja; Oneka, Morgan; Taylor, Peter; Fritsche, Lars G.; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Haug, Eirin B.; Gabrielsen, Maiken E.; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney E.; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Springer Science and Business Media LLC, 2020-08-07)
    Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify ...
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    Implications of Climate Change on Nature-Based Tourism Demand: A Segmentation Analysis of Glacier Site Visitors in Southeast Iceland 
    Welling, Johannes; Árnason, Þorvarður; Olafsdottir, Rannveig (MDPI AG, 2020-07-01)
    Since the end of the 20th century, glaciers are shrinking at an accelerated pace worldwide. This fuels the concern that increased glacier recession will lead to changes in the accessibility, safety, and amenity of many popular glacier tourist ...
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    Glacier tourism and climate change adaptation in Iceland 
    Welling, Johannes (University of Iceland, School of Engineering and Natural Sciences, Faculty of Life and Environmental Sciences, 2020-10)
    Climate change constitutes one of the most pressing challenges faced by tourism today. Tourism research on climate-induced environmental changes has contributed to an increase in knowledge about adaptation during the last decade. Despite a general ...
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    T-patterns, external memory and mass-societies in proteins and humans: In an eye-blink the naked ape became a string-controlled citizen 
    Magnússon, Magnús S. (Elsevier BV, 2020-12-01)
    This project started in the 1970′s inspired by biological behavior research (Morris, 1967; Tinbergen, 1965) including that of N. Tinbergen, K. Lorenz and K. von Frisch, for which they shared a Nobel Prize in 1973 in Medicine or Physiology, the first ...