Opin vísindi

Genomic regions controlling shape variation in the first upper molar of the house mouse

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Pallares, Luisa F
dc.contributor.author Ledevin, Ronan
dc.contributor.author Pantalacci, Sophie
dc.contributor.author Turner, Leslie M
dc.contributor.author Steingrimsson, Eirikur
dc.contributor.author Renaud, Sabrina
dc.date.accessioned 2017-12-22T11:07:19Z
dc.date.available 2017-12-22T11:07:19Z
dc.date.issued 2017-11-01
dc.identifier.citation Luisa F Pallares; Ronan Ledevin; Sophie Pantalacci; Leslie M Turner; Eirikur Steingrimsson; Sabrina Renaud. (2017) Genomic regions controlling shape variation in the first upper molar of the house mouse, eLife (6), e29510. doiI:10.7554/eLife.29510
dc.identifier.issn 2050-084X
dc.identifier.uri https://hdl.handle.net/20.500.11815/493
dc.description.abstract Numerous loci of large effect have been shown to underlie phenotypic variation between species. However, loci with subtle effects are presumably more frequently involved in microevolutionary processes but have rarely been discovered. We explore the genetic basis of shape variation in the first upper molar of hybrid mice between Mus musculus musculus and M. m. domesticus. We performed the first genome-wide association study for molar shape and used 3D surface morphometrics to quantify subtle variation between individuals. We show that many loci of small effect underlie phenotypic variation, and identify five genomic regions associated with tooth shape; one region contained the gene microphthalmia-associated transcription factor Mitf that has previously been associated with tooth malformations. Using a panel of five mutant laboratory strains, we show the effect of the Mitf gene on tooth shape. This is the first report of a gene causing subtle but consistent variation in tooth shape resembling variation in nature.
dc.description.sponsorship Agence Nationale de la Recherche Bigtooth (ANR-11-BSV7-008) Ronan Ledevin Sophie Pantalacci Sabrina Renaud Icelandic Research Fund 152715-053 Eirikur Steingrimsson
dc.format.extent e29510
dc.language.iso en
dc.publisher eLife Sciences Organisation, Ltd.
dc.relation.ispartofseries eLife;6
dc.rights info:eu-repo/semantics/openAccess
dc.subject Húsamús
dc.subject Tennur
dc.subject Erfðagreining
dc.title Genomic regions controlling shape variation in the first upper molar of the house mouse
dc.type info:eu-repo/semantics/article
dcterms.license This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.description.version Peer Reviewed
dc.identifier.journal eLife
dc.identifier.doi 10.7554/eLife.29510
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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