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Genomic regions controlling shape variation in the first upper molar of the house mouse

Genomic regions controlling shape variation in the first upper molar of the house mouse


Titill: Genomic regions controlling shape variation in the first upper molar of the house mouse
Höfundur: Pallares, Luisa F
Ledevin, Ronan
Pantalacci, Sophie
Turner, Leslie M
Steingrimsson, Eirikur   orcid.org/0000-0001-5826-7486
Renaud, Sabrina
Útgáfa: 2017-11-01
Tungumál: Enska
Umfang: e29510
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: eLife;6
ISSN: 2050-084X
DOI: 10.7554/eLife.29510
Efnisorð: Húsamús; Tennur; Erfðagreining
URI: https://hdl.handle.net/20.500.11815/493

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Tilvitnun:

Luisa F Pallares; Ronan Ledevin; Sophie Pantalacci; Leslie M Turner; Eirikur Steingrimsson; Sabrina Renaud. (2017) Genomic regions controlling shape variation in the first upper molar of the house mouse, eLife (6), e29510. doiI:10.7554/eLife.29510

Útdráttur:

Numerous loci of large effect have been shown to underlie phenotypic variation between species. However, loci with subtle effects are presumably more frequently involved in microevolutionary processes but have rarely been discovered. We explore the genetic basis of shape variation in the first upper molar of hybrid mice between Mus musculus musculus and M. m. domesticus. We performed the first genome-wide association study for molar shape and used 3D surface morphometrics to quantify subtle variation between individuals. We show that many loci of small effect underlie phenotypic variation, and identify five genomic regions associated with tooth shape; one region contained the gene microphthalmia-associated transcription factor Mitf that has previously been associated with tooth malformations. Using a panel of five mutant laboratory strains, we show the effect of the Mitf gene on tooth shape. This is the first report of a gene causing subtle but consistent variation in tooth shape resembling variation in nature.

Leyfi:

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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