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Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland

Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland

Title: Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
Author: Norddahl, Gudmundur L.
Melsted, Páll   orcid.org/0000-0002-8418-6724
Gunnarsdottir, Kristbjorg
Halldórsson, Gísli Hreinn
Olafsdottir, Thorunn
Gylfason, Arnaldur
Kristjánsson, Már
Magnusson, Olafur T.
sulem, patrick   orcid.org/0000-0001-7123-6123
Gudbjartsson, Daniel Fannar
... 3 more authors Show all authors
Date: 2022-09-28
Language: English
Scope: 2744365
University/Institute: Landspitali - The National University Hospital of Iceland
School: Health Sciences
Department: Faculty of Industrial Engineering, Mechanical Engineering and Computer Science
Office of Division of Clinical Services I
Other departments
Faculty of Medicine
Series: Nature Communications; 13(1)
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33076-4
Subject: Smitsjúkdómalæknisfræði; Angiotensin-Converting Enzyme 2; Antibodies, Viral/metabolism; BNT162 Vaccine; COVID-19/epidemiology; Humans; Iceland/epidemiology; RNA, Messenger; SARS-CoV-2/genetics; Vaccination; Vaccines, Synthetic; Viral Vaccines; mRNA Vaccines; Multidisciplinary; General Physics and Astronomy; General Chemistry; General Biochemistry,Genetics and Molecular Biology
URI: https://hdl.handle.net/20.500.11815/3522

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Citation:

Norddahl , G L , Melsted , P , Gunnarsdottir , K , Halldórsson , G H , Olafsdottir , T , Gylfason , A , Kristjánsson , M , Magnusson , O T , sulem , P , Gudbjartsson , D F , Þorsteinsdóttir , U , Jónsdóttir , I & Stefánsson , K 2022 , ' Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland ' , Nature Communications , vol. 13 , no. 1 , 5701 , pp. 5701 . https://doi.org/10.1038/s41467-022-33076-4

Abstract:

By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters.

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Publisher Copyright: © 2022, The Author(s).

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