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Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Norddahl, Gudmundur L.
dc.contributor.author Melsted, Páll
dc.contributor.author Gunnarsdottir, Kristbjorg
dc.contributor.author Halldórsson, Gísli Hreinn
dc.contributor.author Olafsdottir, Thorunn
dc.contributor.author Gylfason, Arnaldur
dc.contributor.author Kristjánsson, Már
dc.contributor.author Magnusson, Olafur T.
dc.contributor.author sulem, patrick
dc.contributor.author Gudbjartsson, Daniel Fannar
dc.contributor.author Þorsteinsdóttir, Unnur
dc.contributor.author Jónsdóttir, Ingileif
dc.contributor.author Stefánsson, Kári
dc.date.accessioned 2022-10-18T01:03:36Z
dc.date.available 2022-10-18T01:03:36Z
dc.date.issued 2022-09-28
dc.identifier.citation Norddahl , G L , Melsted , P , Gunnarsdottir , K , Halldórsson , G H , Olafsdottir , T , Gylfason , A , Kristjánsson , M , Magnusson , O T , sulem , P , Gudbjartsson , D F , Þorsteinsdóttir , U , Jónsdóttir , I & Stefánsson , K 2022 , ' Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland ' , Nature Communications , vol. 13 , no. 1 , 5701 , pp. 5701 . https://doi.org/10.1038/s41467-022-33076-4
dc.identifier.issn 2041-1723
dc.identifier.other 61920753
dc.identifier.other 84c48885-f0f1-4db1-910e-5fb29b574edf
dc.identifier.other 85138919120
dc.identifier.other 36171188
dc.identifier.other unpaywall: 10.1038/s41467-022-33076-4
dc.identifier.uri https://hdl.handle.net/20.500.11815/3522
dc.description Publisher Copyright: © 2022, The Author(s).
dc.description.abstract By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters.
dc.format.extent 2744365
dc.format.extent 5701
dc.language.iso en
dc.relation.ispartofseries Nature Communications; 13(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Smitsjúkdómalæknisfræði
dc.subject Angiotensin-Converting Enzyme 2
dc.subject Antibodies, Viral/metabolism
dc.subject BNT162 Vaccine
dc.subject COVID-19/epidemiology
dc.subject Humans
dc.subject Iceland/epidemiology
dc.subject RNA, Messenger
dc.subject SARS-CoV-2/genetics
dc.subject Vaccination
dc.subject Vaccines, Synthetic
dc.subject Viral Vaccines
dc.subject mRNA Vaccines
dc.subject Multidisciplinary
dc.subject General Physics and Astronomy
dc.subject General Chemistry
dc.subject General Biochemistry,Genetics and Molecular Biology
dc.title Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1038/s41467-022-33076-4
dc.relation.url http://www.scopus.com/inward/record.url?scp=85138919120&partnerID=8YFLogxK
dc.contributor.department Faculty of Industrial Engineering, Mechanical Engineering and Computer Science
dc.contributor.department Office of Division of Clinical Services I
dc.contributor.department Other departments
dc.contributor.department Faculty of Medicine
dc.contributor.school Health Sciences


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