Title: | Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer |
Author: |
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Date: | 2020-02-24 |
Language: | English |
Scope: | 1489-1498 |
University/Institute: | Háskóli Íslands University of Iceland |
School: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) |
Department: | Lyfjafræðideild (HÍ) Faculty of Pharmaceutical Sciences (UI) |
Series: | Biomacromolecules;21(4) |
ISSN: | 1525-7797 1526-4602 (eISSN) |
DOI: | 10.1021/acs.biomac.0c00061 |
Subject: | Biodegradable polymers; Mertansine; Cabazitaxel; Breast cancer cells; Lyfjaefnafræði; Fjölliður; Brjóstakrabbamein |
URI: | https://hdl.handle.net/20.500.11815/2378 |
Citation:Pandya, A.D., Øverbye, A., Sahariah, P., Gaware, V.S., Høgset, H., Masson, M., Høgset, A., Mælandsmo, G.M., Skotland, T., Sandvig, K., Iversen, T.-G., 2020. Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer. Biomacromolecules 21, 1489–1498. doi:10.1021/acs.biomac.0c00061
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Abstract:In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC-CS NPs have high loading capacity and strong drug retention due to π-πstacking interactions between the drugs and the aromatic photosensitizer groups of the polymers. CS polymers with 10% of the side chains containing TPC were found to be optimal in terms of drug loading capacity and NP stability. The TPC-CS NPs loaded with MRT or CBZ displayed higher cytotoxicity than the free form of these drugs in the breast cancer cell lines MDA-MB-231 and MDA-MB-468. Furthermore, light-induced photochemical activation of the NPs elicited a strong photodynamic therapy effect on these breast cancer cells. Biodistribution studies in mice showed that most of the TPC-CS NPs accumulated in liver and lungs, but they were also found to be localized in tumors derived from HCT-116 cells. These data suggest that the drug-loaded TPC-CS NPs have a potential in combinatory anticancer therapy and as contrast agents.
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Description:Publisher's version (útgefin grein)
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Rights:This is an open access article published under a Creative Commons Attribution (CC-BY)License, which permits unrestricted use, distribution and reproduction in any medium,provided the author and source are cited
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