dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Ludwig, Michael Z |
dc.contributor.author |
Palsson, Arnar |
dc.contributor.author |
Alekseeva, Elena |
dc.contributor.author |
Bergman, Casey M |
dc.contributor.author |
Nathan, Janaki |
dc.contributor.author |
Kreitman, Martin |
dc.date.accessioned |
2017-03-30T10:15:57Z |
dc.date.available |
2017-03-30T10:15:57Z |
dc.date.issued |
2005-03-15 |
dc.identifier.citation |
Ludwig MZ, Palsson A, Alekseeva E, Bergman CM, Nathan J, Kreitman M (2005) Functional Evolution of a cis-Regulatory Module. PLoS Biol 3(4): e93. doi:10.1371/journal.pbio.0030093 |
dc.identifier.issn |
1545-7885 |
dc.identifier.issn |
1545-7885 (e-ISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/233 |
dc.description.abstract |
Lack of knowledge about how regulatory regions evolve in relation to their structure–function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a functional genetic complementation analysis of a eukaryotic cis-regulatory module—the even-skipped stripe 2 enhancer—from four Drosophila species. The evolution of this enhancer is non-clock-like, with important functional differences between closely related species and functional convergence between distantly related species. Functional divergence is attributable to differences in activation levels rather than spatiotemporal control of gene expression. Our findings have implications for understanding enhancer structure–function, mechanisms of speciation and computational identification of regulatory modules. |
dc.description.sponsorship |
This work was supported by grants from the National Science Foundation (9982715) and the National Institutes of Health (R01 GM61001). |
dc.format.extent |
e93 |
dc.language.iso |
en |
dc.publisher |
Public Library of Science (PLoS) |
dc.relation.ispartofseries |
Plos Biology;3(4) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Biochemistry |
dc.subject |
Genetics and Molecular Biology |
dc.subject |
Agricultural and Biological Sciences |
dc.subject |
Evolution |
dc.subject |
Lífefnafræði |
dc.subject |
Erfðafræði |
dc.subject |
Sameindalíffræði |
dc.subject |
Þróun lífsins |
dc.title |
Functional Evolution of a cis-Regulatory Module |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
Copyright: © 2005 Ludwig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
dc.description.version |
Peer Reviewed |
dc.description.version |
Ritrýnt tímarit |
dc.identifier.journal |
Plos Biology |
dc.identifier.doi |
10.1371/journal.pbio.0030093 |
dc.relation.url |
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0030093 |
dc.contributor.department |
Líf- og umhverfisvísindadeild (HÍ) |
dc.contributor.department |
Faculty of Life and Environmental Sciences (UI) |
dc.contributor.school |
Verkfræði- og náttúruvísindasvið (HÍ) |
dc.contributor.school |
School of Engineering and Natural Sciences (UI) |