dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Bonetto, Giulia |
dc.contributor.author |
Kamen, Yasmine |
dc.contributor.author |
Evans, Kimberley Anne |
dc.contributor.author |
Karadottir, Ragnhildur Thora |
dc.date.accessioned |
2020-12-17T12:13:12Z |
dc.date.available |
2020-12-17T12:13:12Z |
dc.date.issued |
2020-06-11 |
dc.identifier.citation |
Citation: Bonetto G, Kamen Y, Evans KA and Káradóttir RT (2020) Unraveling Myelin Plasticity. Frontiers in Cellular Neuroscience 14:156. doi: 10.3389/fncel.2020.00156 |
dc.identifier.issn |
1662-5102 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2296 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Plasticity in the central nervous system (CNS) allows for responses to changing environmental signals. While the majority of studies on brain plasticity focus on neuronal synapses, myelin plasticity has now begun to emerge as a potential modulator of neuronal networks. Oligodendrocytes (OLs) produce myelin, which provides fast signal transmission, allows for synchronization of neuronal inputs, and helps to maintain neuronal function. Thus, myelination is also thought to be involved in learning. OLs differentiate from oligodendrocyte precursor cells (OPCs), which are distributed throughout the adult brain, and myelination continues into late adulthood. This process is orchestrated by numerous cellular and molecular signals, such as axonal diameter, growth factors, extracellular signaling molecules, and neuronal activity. However, the relative importance of, and cooperation between, these signaling pathways is currently unknown. In this review, we focus on the current knowledge about myelin plasticity in the CNS. We discuss new insights into the link between this type of plasticity, learning and behavior, as well as mechanistic aspects of myelin formation that may underlie myelin plasticity, highlighting OPC diversity in the CNS. |
dc.description.sponsorship |
This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (Grant Agreement No. 771411; RK, GB, and KE); a Wellcome Studentship (102160/Z/13/Z; YK), the Fonds de recherche du Québec-Santé, a scholarship (YK); the Cambridge Commonwealth European and International Trust, a scholarship (YK); and the Lister Institute, a Research Prize (RK). |
dc.format.extent |
156 |
dc.language.iso |
en |
dc.publisher |
Frontiers Media SA |
dc.relation |
info:eu-repo/grantAgreement/EC/H2020/771411 |
dc.relation |
info:eu-repo/grantAgreement/EC/H2020/102160 |
dc.relation.ispartofseries |
Frontiers in Cellular Neuroscience;14 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Glutamate |
dc.subject |
Myelin |
dc.subject |
Myelin plasticity |
dc.subject |
Oligodendrocyte |
dc.subject |
Oligodendrocyte precursor cell |
dc.subject |
Taugakerfi |
dc.title |
Unraveling Myelin Plasticity |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Frontiers in Cellular Neuroscience |
dc.identifier.doi |
10.3389/fncel.2020.00156 |
dc.relation.url |
https://www.frontiersin.org/article/10.3389/fncel.2020.00156/full |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |