dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Värendh, Maria |
dc.contributor.author |
Andersson, Morgan |
dc.contributor.author |
Björnsdóttir, Erla |
dc.contributor.author |
Arnardottir, Erna Sif |
dc.contributor.author |
Gislason, Thorarinn |
dc.contributor.author |
Pack, Allan |
dc.contributor.author |
Hrubos-Strøm, Harald |
dc.contributor.author |
Johannisson, Arne |
dc.contributor.author |
Júlíusson, Sigurður |
dc.date.accessioned |
2020-10-19T14:55:44Z |
dc.date.available |
2020-10-19T14:55:44Z |
dc.date.issued |
2018-09-28 |
dc.identifier.citation |
Värendh, M, Andersson, M, Björnsdóttir, E, et al. PAP treatment in patients with OSA does not induce long‐term nasal obstruction. J Sleep Res. 2019; 28:e12768. https://doi.org/10.1111/jsr.12768 |
dc.identifier.issn |
0962-1105 |
dc.identifier.issn |
1365-2869 (eISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2126 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small interior nasal dimensions increased (p < 0.001) independent of adherence to treatment. Small nasal volume at baseline was a determinant for becoming a non-user of positive airway pressure treatment (odds ratio 2.22, confidence interval 95% 1.35–3.67, p = 0.002). Subjective nasal obstruction decreased 2 years after initiating positive airway treatment in sleep apnea, and objectively small nasal dimensions increased. Small nasal volume at baseline was a negative predictor for positive airway pressure treatment adherence. Maybe most importantly, positive airway pressure treatment did not cause long-term objective or subjective nasal obstruction. |
dc.description.sponsorship |
The authors are thankful to Sigrun Gudmundsdottir and Lovisa Gudmundsdottir, Sleep Department, Landspitali, Reykjavík, Iceland, for all their work with data collection; and Heidar Bergsson and Eyjolfur Sigurdsson for statistical preparation of the data. The authors would also like to show their gratitude to Greg Maislin, Bethany Staley, Brendan Keenan and the other staff at the Centre for Sleep and Circadian Neurobiology at the University of Pennsylvania, who helped analyse the sleep studies and other data of the cohort. Finally, the authors are thankful to Professor Robin L. Anderson, La Trobe University, and Olivia Newton‐John, Cancer Research Institute, for valuable review and English language proofreading |
dc.format.extent |
e12768 |
dc.language.iso |
en |
dc.publisher |
Wiley |
dc.relation.ispartofseries |
Journal of Sleep Research;28(5) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Acoustic measurements |
dc.subject |
Adherence |
dc.subject |
Apnea |
dc.subject |
Breathing |
dc.subject |
Nasal anatomy |
dc.subject |
Nose |
dc.subject |
Survey |
dc.subject |
Kæfisvefn |
dc.subject |
Öndun |
dc.subject |
öNDUNARV |
dc.title |
PAP treatment in patients with OSA does not induce long‐term nasal obstruction |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Journal of Sleep Research |
dc.identifier.doi |
10.1111/jsr.12768 |
dc.relation.url |
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12768 |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |