Opin vísindi

PAP treatment in patients with OSA does not induce long‐term nasal obstruction

PAP treatment in patients with OSA does not induce long‐term nasal obstruction

Title: PAP treatment in patients with OSA does not induce long‐term nasal obstruction
Author: Värendh, Maria   orcid.org/0000-0001-8421-4804
Andersson, Morgan
Björnsdóttir, Erla   orcid.org/0000-0002-6585-5777
Arnardottir, Erna Sif   orcid.org/0000-0003-0877-3529
Gislason, Thorarinn   orcid.org/0000-0002-6773-9876
Pack, Allan   orcid.org/0000-0002-2879-0484
Hrubos-Strøm, Harald   orcid.org/0000-0003-0065-0145
Johannisson, Arne
Júlíusson, Sigurður
Date: 2018-09-28
Language: English
Scope: e12768
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Journal of Sleep Research;28(5)
ISSN: 0962-1105
1365-2869 (eISSN)
DOI: 10.1111/jsr.12768
Subject: Acoustic measurements; Adherence; Apnea; Breathing; Nasal anatomy; Nose; Survey; Kæfisvefn; Öndun; öNDUNARV
URI: https://hdl.handle.net/20.500.11815/2126

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Värendh, M, Andersson, M, Björnsdóttir, E, et al. PAP treatment in patients with OSA does not induce long‐term nasal obstruction. J Sleep Res. 2019; 28:e12768. https://doi.org/10.1111/jsr.12768


We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small interior nasal dimensions increased (p < 0.001) independent of adherence to treatment. Small nasal volume at baseline was a determinant for becoming a non-user of positive airway pressure treatment (odds ratio 2.22, confidence interval 95% 1.35–3.67, p = 0.002). Subjective nasal obstruction decreased 2 years after initiating positive airway treatment in sleep apnea, and objectively small nasal dimensions increased. Small nasal volume at baseline was a negative predictor for positive airway pressure treatment adherence. Maybe most importantly, positive airway pressure treatment did not cause long-term objective or subjective nasal obstruction.


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