Opin vísindi

New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.

Show simple item record

dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Costa, Margarida
dc.contributor.author Coello, Laura
dc.contributor.author Urbatzka, Ralph
dc.contributor.author Pérez, Marta
dc.contributor.author Thorsteinsdóttir, Margrét
dc.date.accessioned 2020-09-07T14:39:10Z
dc.date.available 2020-09-07T14:39:10Z
dc.date.issued 2019-06-22
dc.identifier.citation Costa, M.; Coello, L.; Urbatzka, R.; Pérez, M.; Thorsteinsdottir, M. New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.. Marine Drugs 2019, 17, 375.
dc.identifier.issn 1660-3397
dc.identifier.uri https://hdl.handle.net/20.500.11815/2048
dc.description Publisher's version (útgefin grein)
dc.description.abstract The previously reported 1-(2,4-dihydroxy-5-methylphenyl)ethan-1-one (1), (1’Z)-2-(1’,5’-dimethylhexa-1’,4’-dieny1)-5-methylbenzene-1,4-diol (2), and 1,8-epoxy-1(6),2,4,7,10-bisaborapentaen-4-ol (5) together with four new structures of aromatic bisabolane-related compounds (3, 4, 6, 7) were isolated from the marine sponge Myrmekioderma sp. Compounds 1, 2, and 5 were identified based on spectral data available in the literature. The structures of the four new compounds were experimentally established by 1D and 2D-NMR and (−)-HRESIMS spectral analysis. Cytotoxic and lipid-reducing activities of the isolated compounds were evaluated. None of the isolated compounds were active against the tested cancer cell lines; however, lipid-reducing activity was found for compounds 2–5 and 7 in the zebrafish Nile red fat metabolism assay. This class of compounds should be further explored for their suitability as possible agents for the treatment of lipid metabolic disorders and obesity. View Full-Text
dc.description.sponsorship Funding: The research leading to these results received funding from the Marie Curie Actions of the European Union’s Seventh Framework Programme FP7/2007-2013/ under REA grant agreement No. 607786, BluePharmTrain, and by the European ERA-NET Marine Biotechnology project CYANOBESITY (ERA-MBT/0001/2015), financed by national funds through FCT (Foundation for Science and Technology, Portugal), RANNIS (Icelandic Center of Research, Iceland), and FCT strategic fund UID/Multi/04423/2019. Ralph Urbatzka was supported by FCT grant SFRH/BPD/112287/2015.
dc.format.extent 375
dc.language.iso en
dc.publisher MDPI AG
dc.relation info:eu-repo/grantAgreement/EC/FP7/607786
dc.relation.ispartofseries Marine Drugs;17(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Bioactivity
dc.subject Bisabolane-related compounds
dc.subject Marine sponges
dc.subject Natural compounds
dc.subject Obesity
dc.subject Whole small animal models
dc.subject Náttúruefni (lyfjafræði)
dc.subject Svampdýr
dc.subject Offita
dc.subject Lyfjaefnafræði
dc.title New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.version Peer Reviewed
dc.identifier.journal Marine Drugs
dc.identifier.doi 10.3390/md17060375
dc.relation.url https://www.mdpi.com/1660-3397/17/6/375/pdf
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

Files in this item

This item appears in the following Collection(s)

Show simple item record