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New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.
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| Title: | New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp. |
| Author: |
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| Date: | 2019-06-22 |
| Language: | English |
| Scope: | 375 |
| University/Institute: | Háskóli Íslands University of Iceland |
| School: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) |
| Department: | Lyfjafræðideild (HÍ) Faculty of Pharmaceutical Sciences (UI) |
| Series: | Marine Drugs;17(6) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md17060375 |
| Subject: | Bioactivity; Bisabolane-related compounds; Marine sponges; Natural compounds; Obesity; Whole small animal models; Náttúruefni (lyfjafræði); Svampdýr; Offita; Lyfjaefnafræði |
| URI: | https://hdl.handle.net/20.500.11815/2048 |
Citation:Costa, M.; Coello, L.; Urbatzka, R.; Pérez, M.; Thorsteinsdottir, M. New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.. Marine Drugs 2019, 17, 375.
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Abstract:The previously reported 1-(2,4-dihydroxy-5-methylphenyl)ethan-1-one (1), (1’Z)-2-(1’,5’-dimethylhexa-1’,4’-dieny1)-5-methylbenzene-1,4-diol (2), and 1,8-epoxy-1(6),2,4,7,10-bisaborapentaen-4-ol (5) together with four new structures of aromatic bisabolane-related compounds (3, 4, 6, 7) were isolated from the marine sponge Myrmekioderma sp. Compounds 1, 2, and 5 were identified based on spectral data available in the literature. The structures of the four new compounds were experimentally established by 1D and 2D-NMR and (−)-HRESIMS spectral analysis. Cytotoxic and lipid-reducing activities of the isolated compounds were evaluated. None of the isolated compounds were active against the tested cancer cell lines; however, lipid-reducing activity was found for compounds 2–5 and 7 in the zebrafish Nile red fat metabolism assay. This class of compounds should be further explored for their suitability as possible agents for the treatment of lipid metabolic disorders and obesity. View Full-Text
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Description:Publisher's version (útgefin grein)
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Rights:This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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